自动化学报2018，Vol.44Issue(2)：240-250,11.DOI:10.16383/j.aas.2018.c160673
基于血液供给条件和力学环境的骨折愈合仿真
Fracture Healing Simulation Considering Blood Supply and Mechanics Conditions
摘要
Abstract
A fracture healing model considering mechanical environment and blood supply conditions is proposed to simulate and predict the complex regenerative repair process for tissue.For mechanics condition of fracture fixation and biological factors,a dynamic spatio-temporal model is developed to simulate the complex interactions of mechanical stability,revascularization and tissue differentiation in secondary fracture healing.Unlike previous study,a three-dimensional finite element model is established.The blood perfusion regarded as a spatio-temporal state variable is included into the model to simulate the revascularization process.With finite element method and fuzzy logic,the dynamic model can describe the callus mechanics and biological processes of tissue differentiation.The callus healing process is simulated in Visual Studio 2012 by forward Euler integration method over equidistant time steps iterative loop.Finally,the model predicates the course of interfragmentary movement of two groups with a different axial stability.Through the comparison with the experiment data,it turned out that the simulation result distributed within the scope of the average deviation of the experimental data,which corresponds well to the experiment curve trend and value.The agreement of simulation results with experiment results verifies the accuracy of the fracture healing model and the advantage of the simulating healing process.关键词
骨折愈合/三维模型/模糊规则/组织分化/有限元Key words
Fracture healing/three-dimensional model/fuzzy rules/tissue differentiation/finite element引用本文复制引用
王沫楠..基于血液供给条件和力学环境的骨折愈合仿真[J].自动化学报,2018,44(2):240-250,11.基金项目
国家自然科学基金(61572159),黑龙江省留学回国人员科技项目择优资助重点项目(2013-201401),哈尔滨理工夫学青年拔尖人才项目(201601)资助 Supported by National Natural Science Foundation of China (61572159),Scientific Research Foundation for the Returned Overseas Scholars of Heilongjiang Province (2013-201401),and Science Funds for the Young Innovative Talents of Harbin University of Science and Technology (201601) （61572159）
