中国临床药理学杂志2018，Vol.34Issue(4)：403-405,3.DOI:10.13699/j.cnki.1001-6821.2018.04.003
替格瑞洛和氯吡格雷对颈动脉支架术后患者的血小板抑制的临床疗效与安全性
Clinical efficacy and safety of ticagrelor and clopidogrel on the platelet inhibitory of patients after carotid artery stenting operation by thrombelastogram
摘要
Abstract
Objective To investigate the clinical effect and safety of ticagrelor and clopidogrel on platelet inhibitory of patients after carotid artery stenting(CAS) operation by thrombelastogram.Methods A total of 150 patients with CAS were selected as the research object,randomly divided into two group:75 patients in treatment group and 75 patients in control group.Patients in treatment group received treatment of 180 mg ticagrelor in combination with 300 mg aspirin 1 d before CAS operation,and received treatment of 90 mg ticagrelor,bid in combination with 100 mg aspirin,qd after CAS operation.Patients in control group received treatment of 300 mg clopidogrel in combination with 300 mg aspirin 1 d before CAS operation,and received treatment of 75 mg clopidogrel,qd in combination with 100 mg aspirin,qd after CAS operation.All patients took antiplatelet drugs for at least 3 months after CAS operation and were followed for 3 months.All patients' venous blood samples were collected at 1 d and 30 d after operation.The rate of platelet inhibition was tested.The ischemic events and bleeding events in two groups were recorded and analyzed.Results The platelet inhibition rates at 1 d and 30 d after operation:were (65.41 ± 20.75)％ and (42.66 ± 26.34)％ respectively in the control group;were (87.37 ± 17.12)％ and (81.91 ± 21.18)％ respectively in the treatment group,the difference between two groups was statistically significant (all P ＜ 0.05).The effective rates of platelet inhibition at 1 d after operation:were 98.7％ and 92.0％ respectively in the treatment group and control group.The effective rates of platelet inhibition at 30 d after operation:were 94.7％ and 74.7％ respectively in treatment group and control group,the difference between two groups was statistically significant (all P ＜ 0.05).The rate of ischemic events of control group and treatment group were 37.3％ and 13.3％ respectively,the difference between two groups was statistically significant (P ＜ 0.05).The rate of bleeding events of control group and treatment group were 6.7％ and 4.0％ respectively,and the difference between two groups was not statistically significant (P ＞ 0.05).Conclusion Compared with clopidogrel,ticagrelor shows a better effect of platelet inhibition,and had good security.关键词
血栓弹力图/替格瑞洛/氯吡格雷/血小板抑制/颈动脉支架植入术Key words
thrombelastogram/clopidogrel/ticagrelor/platelet inhibition/carotid artery stenting分类
医药卫生引用本文复制引用
韦俐,华晓莹,杨伊林,彭亚,周鹏,屈晨虹..替格瑞洛和氯吡格雷对颈动脉支架术后患者的血小板抑制的临床疗效与安全性[J].中国临床药理学杂志,2018,34(4):403-405,3.基金项目
江苏省科学技术厅基金资助项目(BL2014035) （BL2014035）
