中国临床药理学杂志2018，Vol.34Issue(4)：475-478,4.DOI:10.13699/j.cnki.1001-6821.2018.04.023
乳腺癌患者化疗药物不良反应情况及影响因素分析
Influence factors of chemotherapy toxicities in breast cancer patients
刘倩欣 1向倩 2张卓 1范洪玮 1赵楠 2崔一民1
作者信息
- 1. 北京大学第一医院药剂科,北京100034
- 2. 北京大学药学院药事管理与临床药学系,北京100191
- 折叠
摘要
Abstract
Objective To investige the adverse drug reactions of breast cancer patients in the First Hospital of Peking University,and evaluate the factors that may have impacts on adverse drug reactions caused by chemotherapy drugs of breast cancer,and to establish the working mode of individualized medication based on the investigation.Methods Follow-up survey of chemotherapy toxicities caused by chemotherapy drugs of breast cancer patients in the First Hospital of Peking University from August 10,2015 to March 31,2017 was conducted;factors such as age,chemotherapy regimen of the breast were statistically analyzed.Results We selected 260 patients who completed the chemotherapy.There are 1 male,259 females,and mean age is(51.33 ± 10.99) years.The common adverse effects of breast cancer include nausea (67.69％),vomiting(36.15％),decreased white blood cell (66.54％),decreased neutrophil count (66.54％),anemia (57.69％),fatigue(53.85％),and taste disorders (40.77％).Drug category has significant influence on chemotherapy toxicity (all P ＜ 0.05).Conclusion This study found that drug category had significant influence on chemotherapy toxicity,therefore,doctors should pay attention to the risk of nausea,vomiting,neurotoxicity and bone marrow suppression,in order to develop appropriate chemotherapy regimens.关键词
乳腺癌/化疗/药物不良反应/影响因素Key words
breast cancer/chemotherapy/adverse drug reaction/influence factor分类
医药卫生引用本文复制引用
刘倩欣,向倩,张卓,范洪玮,赵楠,崔一民..乳腺癌患者化疗药物不良反应情况及影响因素分析[J].中国临床药理学杂志,2018,34(4):475-478,4.
