中国临床医学2018，Vol.25Issue(2)：173-177,5.DOI:10.12025/j.issn.1008-6358.2018.20170990
自制新型内镜多功能圈套器在离体/活体猪胃肠道内镜电切术中的应用评估
Assessment of novel endoscopic multi-functional snare for endoscopic resection in porcine model in vivo and in vitro
摘要
Abstract
Objective:To investigate the feasibility,safety and efficacy of a novel endoscopic multi-functional snare for endoscopic resection of gastrointestinal lesions in a porcine model.Methods:The new endoscopic multi-function snare was used for endoscopic resectionin porcine stomach and porcine intestine in vitro or in vivo,respectively.Under condition of different electrical setting(20 W,30 W,40W),the stimulated resected lesions with diameter of about 1 cm were excised, followed by argon plasma coagulation for the wound.The complete resection rate,wound healing 1 week after resection(in vivo experiment),intraoperative and perioperative complications were observed and recorded.The resected lesions and the wounds were sent for pathological examination to observe the muscularis propria injury.Results:It was shown that all the 9 simulated lesions in the stomach were completely resected in vitro.The resection effect in the intestine in vitro was the best under the low power(20 W),while the escharosis of the intestinal mucosa was obvious under higher voltage settings,so low voltage setting was used in the further experiment in vivo.No muscularis propria injury was observed macroscopically and pathologically in vitro.In gastric surgery in vivo,all the 9 lesions were completely resected and no perforation or bleeding on the wound was observed 1 week after operation.In intestinal surgery in vivo,all the 15 lesions were completely resected,and healing of different degree was observed,no complication was found on the wound,muscularis propria damage was observed in 1 case(6.7%,1/15)1 week after operation.Conclusions:The new multi-functional snare is safe and effective in endoscopic resection in porcine model in vitro and in vivo.It is recommended to set the low power of 20 W during intestinal surgery.关键词
内镜多功能圈套器/新型圈套器/内镜电切/动物实验Key words
endoscopic multi-functional snare/novel snare/endoscopic resection/animal experiment分类
医药卫生引用本文复制引用
田红丽,蔡明琰,诸炎,王蕴,朱胜军,周平红..自制新型内镜多功能圈套器在离体/活体猪胃肠道内镜电切术中的应用评估[J].中国临床医学,2018,25(2):173-177,5.基金项目
国家自然科学基金(81670483,81470811),上海市科委重大项目(16411950400).Supported by National Natural Science Foundation of China(81670483,81470811)and the Major Project of Shanghai Municipal Science and Technology Committee(16411950400). （81670483,81470811）
