中国临床医学2018，Vol.25Issue(2)：203-209,7.DOI:10.12025/j.issn.1008-6358.2018.20180089
基于单中心的卵巢子宫内膜样囊肿起源的卵巢透明细胞癌临床特征及预后分析
Clinical and prognostic characteristics of ovarian clear cell carcinoma deriving from endometriotic cyst based on single center in China
摘要
Abstract
Objective:To analyze and compare the clinical pathological features and prognosis of ovarian clear cell carcinoma(OCCC)deriving or not deriving from endometriotic cyst(EC).Methods:Clinical data of 126 patients who were pathologically diagnosed with OCCC from November 2007 to February 2015 were retrospectively analyzed.The patients were divided into EC group and non-EC group according to the cell origin.The clinical,pathological and prognostic data were compared between groups.Results:Among 126 OCCC,46(36.5%)originated from EC(EC group)and 80(63.5%)did not originate from EC(non-EC group).Compared with non-EC group,the patients in EC group were younger at the time of diagnosis([50.1 ± 5.6]years old vs[53.3 ± 8.6]years old,P=0.011)and less likely to be multiparous(100.0% vs 87.5%, P=0.012),with more unilateral ovarian involvement(95.7% vs 82.5%,P= 0.033)and higher ratio of preoperative CA125 ≤200 U/mL(94.9% vs 60.8%,P<0.001).The patients in EC group were more likely to be at early FIGO stage (95.7% vs 58.8%,P<0.001)with higher cytoreduction(100.0% vs 91.3%,P=0.039)and chemosensitivity rate(93.3%vs 71.2%,P= 0.04).EC group showed better progression-free survival(PFS)and overall survival(OS)in Kaplan-Meier survival curve compared with non-EC group.Univariate and multivariate analysis showed that EC origin was not an independent predictor of survival outcome,while the tumor stage and chemosensitivity were the independent prognostic factors for PFS and the chemosensitivity was the only independent prognostic factor for OS.Conclusions:OCCC deriving from EC has more favorable factors for survival outcome compared with OCCC not deriving from EC,while EC origin is not an independent prognostic factor.关键词
卵巢透明细胞癌/子宫内膜异位症/恶变/临床病理特征Key words
ovarian cleacell carcinoma/endometrosis/malignant transformation/clinicopathological features分类
医药卫生引用本文复制引用
唐浩莎,王肖,刘艳,卢媛..基于单中心的卵巢子宫内膜样囊肿起源的卵巢透明细胞癌临床特征及预后分析[J].中国临床医学,2018,25(2):203-209,7.基金项目
上海市卫生和计划生育委员会面上项目(201540224).Supported by General Program of Shanghai Municipal Commission of Health and Fammily Planning(201540224). （201540224）
