中国临床医学2018，Vol.25Issue(2)：266-269,4.DOI:10.12025/j.issn.1008-6358.2018.20170466
帕金森病伴认知障碍患者血尿酸的变化及相关因素分析
Level of blood uric acid in Parkinson disease complicated with cognitive impairment and related factors analysis
摘要
Abstract
Objective:To explore the relationship between cognitive dysfunction and blood acid changes in patients with Parkinson disease,and to analyze the influence factors of cognitive dysfunction.Methods:Totally sixty patients with Parkinson disease in our hospital from January 2014 to December 2016 were enrolled.The cognitive impairment was assessed using Montreal Cognitive Assessment Scale(MoCA)and the patients was graded using Hoehn & Yahr Parkinson disease severity(H-Y).The age,sex,gender,course of disease and education level were retrospectively analyzed to explore the relevant factors of cognitive dysfunction.The levels of serum uric acid and urine microalbumin were detected and compared with healthy subjects(60 cases),and the relationship of blood uric acid and cognitive impairment was analyzed.Results:The level of serum uric acid in Parkinson disease group was(258.0 ± 55.6)μmol/L,being significantly lower than that in healthy group ([328.6 ± 50.8]μmol/L),while the level of urine microalbumin was not significantly different between two groups.No significant difference was found between patients in early stage and advanced stage.In patients with cognitive dysfunction,the level of serum uric acid was(235.6 ± 65.3)μmol/L,being significantly lower than that in patients without cognitive impairment([272.3 ± 60.3]μmol/L,P< 0.05).MoCA score of Parkinson patients was positively correlated with level of serum uric acid and duration of education,and was negatively correlated with course of disease and H-Y grade.Conclusions:Uric acid in serum may be involved in pathogenesis of cognitive impairment in Parkinson disease.Intervention of serum uric acid level is helpful to delay the course of disease.关键词
帕金森病/认知障碍/血尿酸Key words
Parkinson disease/cognitivimpairment/bloouric acilevel分类
医药卫生引用本文复制引用
王庆广,杜春艳,韩伯军,洪珊珊,刘定华..帕金森病伴认知障碍患者血尿酸的变化及相关因素分析[J].中国临床医学,2018,25(2):266-269,4.基金项目
无锡市卫生局科研立项(Q201511).Supported by Wuxi Health Bureau Scientific Research Project of Jiangsu Province(Q201511). （Q201511）
