中国临床医学2018，Vol.25Issue(2)：275-277,3.DOI:10.12025/j.issn.1008-6358.2018.20180140
慢性自发性荨麻疹患者血清差异表达蛋白的筛选及C反应蛋白的测定
Screening of differential expression proteins in serum and detection of C-reactive protein in patients with chronic spontaneous urticaria
摘要
Abstract
Objective:To investigate the relationship of C-reactive protein expression in serum with duration time of wheals in patients with chronic spontaneous urticaria(CSU).Methods:The differential proteins in serum in CSU patients with different duration time of wheals were identified using isobaric tag for relative absolute quantitation(iTRAQ)and the expression of CRP in serum was analyzed.The levels of serum CRP in CSU patients were detectedby immune nephelometry.Results:The level of CRP in serum was up-regulated in CSU patients(P<0.05).The expression of CRP in serum was significantly higher in CSU patients with longer duration of wheals than that in CSU patients with shorter duration of wheals(P< 0.05). Conclusions:The expression of serum CRP is related to duration time of wheals in CSU patients.关键词
慢性自发性荨麻疹/C反应蛋白/iTRAQKey words
chronic spontaneouurticaria/C-reaction protion/iTRAQ分类
医药卫生引用本文复制引用
徐顺明,曹艳云,孔伟,徐徉,蔡海斌..慢性自发性荨麻疹患者血清差异表达蛋白的筛选及C反应蛋白的测定[J].中国临床医学,2018,25(2):275-277,3.基金项目
上海市浦东新区科委研究课题(PKJ2015-Y28),上海市浦东新区卫计委重点专科(PWZzk2017-28).Supported by Research Subject of Science and Technology Bureau of Pudong New Area in Shanghai(PKJ2015-Y28)and Shanghai Pudong New Area Health Planning Commission Key Specialist(PWZzk2017-28). （PKJ2015-Y28）
