中国临床医学2018，Vol.25Issue(2)：278-281,4.DOI:10.12025/j.issn.1008-6358.2018.20170798
宫颈癌及癌前病变中Ki-67、P16蛋白的表达差异及诊断价值
Expression of Ki-67,P16 in cervical cancer and precancerous lesions and their diagnostic value
刘峰 1张春霞 1张莉 1于云英1
作者信息
- 1. 胜利油田中心医院妇产科,东营 257000
- 折叠
摘要
Abstract
Objective:To explore the clinical significance of Ki-67 and P16 in cervical cancer and precancerous lesion. Methods:We selected 90 cases of cervical intraepithelial neoplasia(CIN)and 40 cases of cervical cancer patients of our hospital from August 2014 to August 2016 as a clinical research object,using the immunohistochemical staining method to detect patients with pathological tissue specimens in the expression of P16 and Ki-67,comprehensive analysis of cervical cancer and precancerous lesions in the Ki-67 and compare the differences in the levels of P16 expression and its significance in clinical diagnosis.Results:Ki-67 and P16 were both expressed in cervical and precancerous lesions,the positive rate of Ki-67 in CIN was significantly lower than that in cervical cancer,but the expression of Ki-67 in CIN patients was significantly higher than that in low grade CIN patients(P<0.05).The positive expression rate of P16 in cervical cancer was significantly higher than that in CIN and low grade CIN(P<0.05).the positive expression rate of P16 in low grade CIN was significantly lower than that in CIN(P<0.05).The sensitivity of P16 in the differential diagnosis of CIN and cervical cancer was significantly higher than that of Ki-67(P<0.05).The sensitivity and specificity of P16 in the diagnosis of low grade CIN and high grade CIN were significantly lower than that of Ki-67,and there was no significant difference between groups.The sensitivity of Ki-67 and P16 joint diagnosis in distinguishing CIN and cervical cancer and low grade CIN and high grade CIN were significantly higher than that in single diagnosis(P<0.05).The specificity of differential diagnosis for CIN and cervical cancer was the same as Ki-67.Conclusions:Ki-67 and P16 have some expression in cervical cancer and precancerous lesion,and the joint diagnosis between Ki-67 and P16 is important in the diagnosis of CIN and the diagnosis of cervical cancer.关键词
Ki-67/P16/宫颈癌/癌前病变Key words
Ki-67/P16/cervical cancer/precanceroulesions分类
医药卫生引用本文复制引用
刘峰,张春霞,张莉,于云英..宫颈癌及癌前病变中Ki-67、P16蛋白的表达差异及诊断价值[J].中国临床医学,2018,25(2):278-281,4.
