中国临床医学2018，Vol.25Issue(2)：300-306,7.DOI:10.12025/j.issn.1008-6358.2018.20180043
基于血管平滑肌视角的牵张应力对血管重构影响的研究进展
Effect of stretch stress on vascular remodeling--from perspective of vascular smooth muscle:recent progress
摘要
Abstract
Vascular remodeling is both the initiating factor and final destination in various cardiovascular diseases. Different extents of vascular remodeling participate in the pathophysiology progress of atherosclerosis,hypertension and coronary artery stenting.Stretch stress is a biomechanical force generated by pulsatile blood flow.Abnormal stretch stress acts on smooth muscle cell can result in events such as atherosclerosis and in-stent restenosis,etc.The purpose of this review is to summarize the effects of stretch stress on vascular remodeling from the perspective of vascular smooth muscle cells,in order to provide insights into the research of atherosclerosis and hypertension as well as the development of next generation of bioresorbable vascular scaffold.关键词
血管重构/牵张应力/信号传导/血管平滑肌细胞/研究进展Key words
vascularemodeling/stretch stress/cell signaling/vasculasmooth musclcell/research progress分类
医药卫生引用本文复制引用
王瑞,沈雳..基于血管平滑肌视角的牵张应力对血管重构影响的研究进展[J].中国临床医学,2018,25(2):300-306,7.基金项目
国家自然科学基金(81670319).Supported by National Natural Science Foundation of China(81670319). （81670319）
