中国现代医学杂志2018，Vol.28Issue(12)：32-35,4.DOI:10.3969/j.issn.1005-8982.2018.12.005
甲型肝炎患者黏蛋白域蛋白1和4表达与抗体产生的相关性研究
Effect of TIM-1 and TIM-4 on immunity in recovery stage of hepatitis patients
摘要
Abstract
Objective To study the correlation between T cell immunoglobulin domain and mucin domain-1 (TIM-1) and TIM-4 and humoral immunity in recovery stage of hepatitis patients. Methods A total of 60 hepatitis patients on recovery period were chosen, and 60 healthy volunteers were involved in control group. qRT-PCR were utilized to measure expression levels of TIM-1 and TIM-4. Levels of IL-4, IL-10, TNF-α and total serum Ig were identified by ELISA. Results Expression levels of TIM-1 and TIM-4 were upregulated significantly in hepatitis patients compared with control group (P < 0.05). Serum IL-4, IL-10 and total Ig increased significantly in hepatitis patients when compared with control group (P < 0.05). Conclusion TIM-1 and TIM-4 may enhance the humoral immunity by upregulating cytokines such as IL-4 and IL-10.关键词
T细胞免疫球蛋白及黏蛋白域蛋白1/辅助性T细胞/体液免疫Key words
T-cell immunoglobulin domain and mucin domain 1/T helper cell/humoral immune分类
医药卫生引用本文复制引用
胡耀华,阳慧,吴翔,符春苗,邵运禄,郑才玲,卓书伟..甲型肝炎患者黏蛋白域蛋白1和4表达与抗体产生的相关性研究[J].中国现代医学杂志,2018,28(12):32-35,4.基金项目
海南省卫生厅课题(No:15A200012) （No:15A200012）
