中国现代医学杂志2018，Vol.28Issue(12)：43-48,6.DOI:10.3969/j.issn.1005-8982.2018.12.007
乳腺浸润性导管癌TOP2A基因与相关蛋白及临床病理特征的相关性分析
Correlation analysis between TOP2A gene and breast invasive ductal carcinoma
赵丽辉 1易冰 1孟凤娇2
作者信息
- 1. 广东省中山市人民医院 分子诊断中心,广东 中山 528403
- 2. 广东省中山市人民医院 病理科,广东 中山 528403
- 折叠
摘要
Abstract
Objective To investigate the correlation between topoisomerase Ⅱα ( TOP2A) gene and breast invasive ductal carcinoma. Methods Totally 371 patients with breast invasive ductal carcinoma were included in this study.Abnormalities of TOP2A gene was determined.Expression of ER,PR,Ki67 and HER2 were measured. Clinical characteristics of patients were recorded. Results The abnormal rate of TOP2A gene was 20.49%(76/371), among which were gene amplification (64, 17.25%), gene deletion (12, 3.24%). No obvious relationship was observed between abnormality of TOP2A and age,gender,site,axillary lymph node metastasis orexpression of ER and PR (P>0.05).Abnormality of TOP2A was positively associated with tumor size and enhance dexpression of Ki67 and HER2(P<0.05). Conclusions Abnormality of TOP2A gene provides fundamental evidence for anthracycline as therapeutic approach for patients with breast invasive ductal carcinoma.关键词
TOP2A基因/乳腺浸润性导管癌/Ki67/HER2Key words
TOP2A gene/breast invasive ductal carcinoma/ki67/HER2分类
医药卫生引用本文复制引用
赵丽辉,易冰,孟凤娇..乳腺浸润性导管癌TOP2A基因与相关蛋白及临床病理特征的相关性分析[J].中国现代医学杂志,2018,28(12):43-48,6.
