中国现代医学杂志2018，Vol.28Issue(12)：49-52,4.DOI:10.3969/j.issn.1005-8982.2018.12.008
初发急性白血病患者骨髓乳腺癌耐药蛋白基因表达及其与预后关系的研究
Prognostic significance of breast cancer resistance protein in primary acute leukemia patients
刘劲 1李薇 2段华新 1罗科玲 2周煦3
作者信息
- 1. 湖南省人民医院肿瘤科,湖南 长沙 410005
- 2. 湖南省人民医院血液科,湖南 长沙 410005
- 3. 湖南省人民医院重症医学科,湖南 长沙 410005
- 折叠
摘要
Abstract
Objective To investigate the gene expression of breast cancer resistance protein (BCRP) in bone marrow of acute leukemia (AL) and its prognosis. Methods A total of 67 AL patients admitted in our hospital from January 2014 to December 2014 were enrolled in the study, and 10 healthy volunteers were involved as control group. Real-time PCR was utilized to measure the gene expression of BCRP in bone marrow. And the difference in the BCRP gene expression and its prognosis were analyzed. Results The gene expression of BCRP in bone marrow of AL patients was statistically higher than that in the healthy volunteer group (P < 0.01). Acute leukemia patients were divided into high BCRP group and low BCRP group according to the mean of BCRP (3.0). Compared with low BCRP group, the primary WBC count was higher in BCRP high group (P < 0.01). The survival analysis between the two groups was statistically significant (Log-rank = 21.78, P < 0.05). Conclusion The gene expression of BCRP in bone marrow of AL patients was statistically increased and associated with the prognosis. High BCRP gene expression was a risk factor for poor prognosis in patients with AL.关键词
急性白血病/乳腺癌耐药蛋白/基因表达/预后Key words
acute leukemia/breast cancer resistance protein (BCRP)/gene expression/prognosis分类
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刘劲,李薇,段华新,罗科玲,周煦..初发急性白血病患者骨髓乳腺癌耐药蛋白基因表达及其与预后关系的研究[J].中国现代医学杂志,2018,28(12):49-52,4.
