中国现代医学杂志2018，Vol.28Issue(12)：69-73,5.DOI:10.3969/j.issn.1005-8982.2018.12.012
肺炎支原体感染对川崎病患儿的影响
Effect of mycoplasma pneumoniae infection on children with Kawasaki disease
摘要
Abstract
Objective To investigate the effect of mycoplasma pneumoniae (MP) infection on inflammatory status and coronary artery lesions (CAL) in Kawasaki disease (KD) children. Methods Totally 128 children with KD were divided into MP group (n = 42) and non-MP group (n = 86). The clinical features of the groups including fever duration, proportion of incomplete KD and IVIG resistance were recorded. White blood cell count (WBC), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), high sensitive C reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), ratio of LCA/AOA and incidence of CAL were compared. Results NLR, PLR, hs-CRP, ESR and PLT in acute phase of MP patients were significantly increased compared with non-MP group (P < 0.05); hs-CRP and PLR in remission phase of MP group were significantly upregulated when compared with non-MP group (P < 0.05). Patients in MP group experienced increased incidence of IVIG resistance, CAL and ratio of LCA/AOA compared with non-MP infection group (P < 0.05). Conclusions KD children with MP infection have more severe inflammatory response and higher risk of IVIG resistance and CAL.关键词
川崎病/肺炎支原体/免疫炎症反应/冠状动脉损害Key words
Kawasaki disease/mycoplasma pneumoniae/inflammatory immune response/coronary artery lesions分类
医药卫生引用本文复制引用
王晓华,赵建美..肺炎支原体感染对川崎病患儿的影响[J].中国现代医学杂志,2018,28(12):69-73,5.基金项目
江苏省卫生厅科研项目(No:H201423) （No:H201423）
南通市科技计划项目(MS22015071) （MS22015071）
江苏省卫计委妇幼健康科研项目(No:F201751) （No:F201751）
