中国现代医学杂志2018，Vol.28Issue(12)：86-89,4.DOI:10.3969/j.issn.1005-8982.2018.12.015
无创性肢体远隔缺血后处理对脑卒中患者血清指标影响的临床研究
Effect of noninvasive limb distal ischemic postconditioning on serum markers in stroke patients
摘要
Abstract
Objective To investigate the effect of posterior ischemic postconditioning (RIPostC) on serum markers in patients with ischemic stroke and potential clinical significance. Methods Totally 200 patients with ischemic stroke admitted in our hospital from January 2016 to June 2017 were enrolled. Patients received standard treatments. They were randomly divided into: experimental group who received additional RIPostC for 12 months (n = 100) and control group that no extra treatments were performed (n = 100). Serum levels of homocysteine, lipid levels (high density lipoprotein, total cholesterol), platelet aggregation rate and ischemic modified albumin were measured before and after thetreatments. Results Patients in both groups experienced increased levels of serum total cysteine, total cholesterol, platelet aggregation rate and ischemic albumin and decreased levels of high density lipoprotein prior to any treatments. No significant difference (P > 0.05) in serum markers were identified between the two groups. Standard treatment induced decrease of serum cysteine, total cholesterol, platelet aggregation rate and ischemic albumin and increase of HDL in the two groups (P < 0.05). Treatment of RIPostC witnessed more dramatic alteration of serum biomarkers compared to control group (P < 0.05). Conclusion RIPostC therapy effectively reduces the severity of ischemic stroke, promoting better prognostic outcome.关键词
远隔缺血后适应/缺血性脑卒中/同型半胱氨酸/血小板聚集率/缺血修饰白蛋白Key words
posterior ischemic postconditioning/ischemic stroke/homocysteine/platelet aggregation rate/ischemic modified albumin分类
医药卫生引用本文复制引用
丁文婷,王心颖,徐英辉,高倩,崔永健,魏琰..无创性肢体远隔缺血后处理对脑卒中患者血清指标影响的临床研究[J].中国现代医学杂志,2018,28(12):86-89,4.基金项目
2016年衡水市科技计划项目(No:2016014115Z) （No:2016014115Z）
