摘要
Abstract
Objective To analyze the relationship between abnormal metabolic indices and cardiac vascular disease (CVD) in adolescents with metabolic syndrome (MS). Methods Totally 288 adolescents with MS (MS group) and 250 healthy adolescents (NC group) were selected and the clinical data and biochemical indices were collected and compared between the two groups. Then MS group were further divided into Male group (n = 167) and Female group (n = 121) to observe metabolic components distribution. Correlation between abnormal metabolic indices and CVD were analyzed by Logistic regression analysis. Results WC, BMI, SBP, DBP, FPG, FINS, TG, TC, SUA and HOMA-IR were higher while LDL-C were lower in MS group than those in NC group, respectively (P <0.05); the positive rates of abnormal metabolic indices were higher in MS group than thosein NC group in the same sex crowd (P < 0.05), while there were no statistically significant differencesin positive rate of abnormal metabolic indices in different gender groups (P > 0.05); WC, BMI, SBP, FPG, FIns and HOMA-IR were lower in Female group than those in Male group (P < 0.05); After factors adjustment of age, gender and puberty, onset risk of CVD in MS adolescents, male and female were 17.5 times (95% CI: 10.23, 49.37), 9.74 times (95% CI: 3.60, 30.25) and 9.01 times (95% CI: 3.08, 26.40) of those in normal adolescents respectively. The highest risk of abnormal metabolic indicesand CVD in MS adolescents, male and female were BP ≥ 130/85 mmHg (O^R = 5.18, 95%CI: 3.56, 7.51), BP ≥ 130/85 mmHg (O^R = 2.35, 95% CI: 1.25, 4.41) and high WC (O^R = 2.84, 95% CI: 1.73, 4.68). Conclusion The risk of CVD is increased in MS adolescents; the highest risk of cardiovascular event in MS adolescents and female is high BP, and the highest risk of CVD in MS mamle is high WC .关键词
青少年/代谢综合征/代谢组分/心血管疾病/相关性Key words
adolescent/metabolic syndrome/metabolic indices/cardiac vascular disease/relationship分类
医药卫生
