中国现代医学杂志2018，Vol.28Issue(12)：101-104,4.DOI:10.3969/j.issn.1005-8982.2018.12.018
阻塞性睡眠呼吸暂停低通气综合征患者血清HIF-1α和VEGF水平及其与血压的关系
Relationship between hypoxia inducible factor-1α, vascular endothelial growth factor and blood pressure in patients with obstructive sleep apnea hypopnea syndrome
曹悦鞍 1盛晓燕 2李丽华 2田力 1彭朝胜1
作者信息
- 1. 中国人民解放军海军总医院 特需医疗部,北京 100048
- 2. 南昌三三四医院 内科,江西 南昌 330024
- 折叠
摘要
Abstract
Objective To investigate the relationship between hypoxia inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and blood pressure in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods The survey was conducted in 130 patients selected from the special care medical center of Naval General Hospital of PLA from January 2013 to October 2016. The ambulatory blood pressure monitoring (ABMP) and polysomnography (PSG) were determined. According to the result of PSG test, 130 subjects were divided into obstructive sleep apnea hypopnea syndrome group (n = 80) and normal control group (n = 50). The level of serum HIF-1α and VEGF were detected by ELISA method. The parameters of the blood pressure were compared in the two groups and the relationship between HIF-1α, VEGF, apnea hypoventilation index (AHI) and blood pressure were comparatively analyzed in obstructive sleep apnea hypopnea syndrome group. Results For the patients with obstructive sleep apnea hypopnea syndrome, the levels of HIF-1α and VEGF were significantly higher than those of normal control group (P < 0.05), they were positively correlated with AHI (P < 0.05). The night mean systolic blood pressure (nSBP) and night mean diastolic blood pressure (nDBP) were significantly higher in obstructive sleep apnea hypopnea syndrome group (P < 0.05). Conclusion HIF-1α and VEGF may be risk factors which can influence night blood pressure in patients with obstructive sleep apnea hypopnea syndrome.关键词
阻塞性睡眠呼吸暂停低通气综合征/低氧诱导因子1α血管内皮生长因子/血压Key words
Keyword: obstructive sleep apnea hypopnea syndrome/hypoxia inducible factor-1α/vascular endothelial growth factor/blood pressure分类
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曹悦鞍,盛晓燕,李丽华,田力,彭朝胜..阻塞性睡眠呼吸暂停低通气综合征患者血清HIF-1α和VEGF水平及其与血压的关系[J].中国现代医学杂志,2018,28(12):101-104,4.
