中国药理学通报2018，Vol.34Issue(5)：593-596,4.DOI:10.3969/j.issn.1001-1978.2018.05.001
二甲双胍非降糖肾脏保护作用的研究新进展
Non-hypoglycemic effect of metformin in renal protection:a literature review
摘要
Abstract
The effectiveness,safety and economy of metformin on type 2 diabetes mellitus therapy are well recognized, which has been used as the first-line oral hypoglycemic agent in recent dec-ades. Apart from hypoglycemic effect, recent studies show that metformin can exert renal protection via the mechanisms of auto-phagy induction, anti-senescence, antioxidative stress, against endoplasmic reticulum stress,anti-inflammation, and anti-fibro-sis through AMPK dependent or independent pathway, which prompt its therapeutic potential in acute kidney injury and chron-ic kidney disease. The non-hypoglycemic nephroprotective effects as well as their underlying mechanisms of metformin are summarized in this review.关键词
二甲双胍/非降糖作用/肾脏保护/AMPK/慢性肾脏病/急性肾损伤Key words
metformin/non-hypoglycemic effect/renal protec-tion/AMPK/chronic kidney disease/acute kidney injury分类
医药卫生引用本文复制引用
薛晶,杨陈,安宁,刘华锋..二甲双胍非降糖肾脏保护作用的研究新进展[J].中国药理学通报,2018,34(5):593-596,4.基金项目
国家自然科学基金资助项目(No 81670654) （No 81670654）
广东省医学科研基金资助项目(No A2016135) （No A2016135）
