中国药理学通报2018，Vol.34Issue(5)：600-603,4.DOI:10.3969/j.issn.1001-1978.2018.05.003
上皮间质转化与哮喘气道重塑的研究进展
Advances on epithelial mesenchymal transformation and airway remodeling of asthma
摘要
Abstract
Bronchial asthma is a respiratory system disease char-acterized by airway remodeling as a pathological basis. Repeated inflammatory infiltration and tissue damage repair can lead to airway remodeling. At present,the mechanism of airway remod-eling is not comprehensive. Studies have shown that epithelial-mesenchymal transition (EMT) plays an important role in the genesis and development of airway remodeling. Airway epithelial cells can be induced to mesenchymal transition through a variety of secretion factors and signaling pathways,leading to airway re-modeling in asthma. This review summarizes the study of EMT and airway remodeling in asthma,providing a reference for clini-cal follow-up treatment and research.关键词
气道重塑/上皮间质转化/哮喘/结构蛋白/表型转化/气道炎症Key words
airway remodeling/epithelial-mesenchymal transi-tion/asthma/structural protein/phenotypic transformation/air-way inflammation分类
医药卫生引用本文复制引用
魏盼,李恋曲,吴鹏,贾志荣,王晓钰,洪敏,江国荣..上皮间质转化与哮喘气道重塑的研究进展[J].中国药理学通报,2018,34(5):600-603,4.基金项目
国家自然科学基金资助项目(No 81473395,81373549) （No 81473395,81373549）
江苏省自然科学基金资助项目(No BK20141466) （No BK20141466）
江苏省儿童呼吸疾病(中医药)重点实验室资助项目(No JKLPRD201405) （中医药）
江苏高校优势学科建设工程资助项目 （）
