中国药理学通报2018，Vol.34Issue(5)：712-716,5.DOI:10.3969/j.issn.1001-1978.2018.05.024
乳源免疫调节肽对小鼠急性酒精性肝损伤的保护作用
Protective effect of immunomodulating peptide(PGPIPN) derived from beta-casomorphin in bovine milk on acute alcohol-induced liver injury
摘要
Abstract
Aim To investigate the protective effect of immunomodulating peptide(PGPIPN) on the acute al-coholic liver injury in mice. Methods Kunming mice were randomly divided into control group, model group,glutataione(GSH) group, PGPIPN low dose group, PGPIPN moderate and high dose groups. The mice were treated with different doses of PGPIPN or GSH for two weeks except control group and model group. The acute alcoholic liver injury model was in-duced by gavage with 56° alcohol for three days. The indices including the activities of AST,ALT in serum, and the contents of TNF-α, MDA, SOD and GSH-Px in liver were examined. Liver histopathological changes were examined by HE staining. Results Compared with control group,the levels of serum ALT,AST and the contents of TNF-α, MDA significantly increased, while the contents of SOD and GSH-Px significantly de-creased in model group. There was hepatocyte apopto-sis and inflammatory cell infiltration in liver tissues. Compared with model group, the activities of serum ALT, AST and the contents of TNF-α, MDA were re-markably reduced in PGPIPN high dose group. The contents of SOD and GSH-Px significantly increased in PGPIPN high dose group. PGPIPN could alleviate the injury of liver. Conclusion PGPIPN has certain pro-tective effect on acute alcoholic liver injury of mice, providing a theoretical guidance.关键词
乳源免疫调节肽/小鼠/急性酒精性肝损伤/生化指标/氧化应激/保护作用Key words
PGPIPN/mice/acute alcoholic liver in-jury/biochemical indices/oxidative stress/protective effect分类
医药卫生引用本文复制引用
顾芳,席浩,阮昕,徐恰,汪慎燚,秦宜德..乳源免疫调节肽对小鼠急性酒精性肝损伤的保护作用[J].中国药理学通报,2018,34(5):712-716,5.基金项目
国家自然科学基金资助项目(No 81472448) （No 81472448）
安徽省高校自然科学研究重点项目(No KJ2017A182) （No KJ2017A182）
