重庆医学2018，Vol.47Issue(11)：1457-1459,1464,4.DOI:10.3969/j.issn.1671-8348.2018.11.007
IL-17A启动子基因多态性与冠心病患者血脂和炎症因子的关联性研究
Association of IL-17 A gene promoter polymorphism with blood lipid and inflammatory factors in patients with coronary heart disease
摘要
Abstract
Objective To investigate the association between interleukin-17 A (IL-17 A) gene promoter polymorphism and blood lipid and inflammatory factors in coronary heart disease.Methods A total of 241 patients with coronary heart disease who were admitted to hospital from April 2010 to December 2016 were enrolled in this study.68 cases of healthy subjects were collected.IL-17 gene promoter rs8193036 genotype,blood lipid and inflammatory factors were detected and compared.Results Compared with the control group,the genotype CC,CT and TT of the rs8193036 genotype in the coronary heart disease group were significantly different (P＜0.05),and the frequency of C allele in the coronary heart disease group was significantly higher than that in the control group (P＜0.05).The levels of triglyceride,low-density lipoproteinCholesterol,high density lipoprotein cholesterol,interleukin-17a,interleukin-6,interleukin-8 and tumor necrosis factor alpha in CC genotype of tumor necrosis factor alpha group were significantly higher than those in tumor necrosis factor alpha group (P＜0.05),high density lipoprotein cholesterol decreased significantly (P＜0.05).Total cholesterol and low-density lipoprotein cholesterol had no significant differences (P ＞ 0.05).Conclusion The rs8193036 polymorphism of IL-17A gene promoter is associated with the pathogenesis of coronary heart disease.The C allele is an important genetic marker of coronary heart disease.The polymorphism of IL-17A promoter rs8193036 might affect coronary heart disease by increasing blood lipids and inflammation factors.关键词
白细胞介素-17A/冠心病/基因多态性/血脂/炎症因子Key words
interleukin-17A/coronary heart disease/gene polymorphism/lipid/inflammatory factor分类
医药卫生引用本文复制引用
张倩辉,谢悦陶,党懿,苑可心,刘月欣,李树仁..IL-17A启动子基因多态性与冠心病患者血脂和炎症因子的关联性研究[J].重庆医学,2018,47(11):1457-1459,1464,4.基金项目
河北省医学科学研究重点课题(20170019). （20170019）
