重庆医学2018，Vol.47Issue(11)：1460-1464,5.DOI:10.3969/j.issn.1671-8348.2018.11.008
系统性红斑狼疮合并间质性肺炎的临床特征及相关危险因素分析
Clinical characteristics and correlative risk factors of interstitial pneumonia in systemic lupus erythematosus
摘要
Abstract
Objective To study the clinical characteristics and analyze the correlative risk factors of interstitial pneumonia in systemic lupus erythematosus (SLE-IP).Methods 80 SLE patients in department of rheumatology of Nanfang hospital form January 2013 to January 2016 were retrospectively analyzed.SLE patients with interstitial pneumonia (n=40) were divided into case group.40 cases of SLE with interstitial pneumonia were selected and matched with age and sex.Patients with mild SLE without interstitial pneumonia were treated as controls.The clinical manifestations,routine examination,biochemical examination and immunological examination were performed to compare the risk factors of SLE-related interstitial pneumonia.Results In this study,non-specific interstitial pneumonia (NSIP) and usual interstitial pneumonia (UIP) were common in SLE-IP patients.the ground-glass opacities were more common in NSIP type,while Grid shadows and honeycomb shadows were more common in UIP type.The dry cough,chest tightness / shortness of breath,Raynaud's phenomenon,wet rales,triglyceride increased,anti-Sm antibody positive rate,anti-U1-nRNP positive rate between two groups were statistically significant (P＜0.05).Logistic regression analysis showed that the risk factors of SLE-IP were dry cough,chest tightness / shortness of breath,Raynaud's phenomenon,wet rales,triglyceride increased,anti-Sm antibody positive and anti-U1-nRNP positive.Conclusion The presence of dry cough,chest tightness / shortness of breath,Raynaud's phenomenon,wet rales,triglyceride increased,anti-Sm antibody positive and anti-U1-nRNP positive all suggest the probability of interstitial pneumonia in SLE patients.HRCT plays an important role in the diagnosis of interstitial pneumonia in lupus,which is valuable to improve the prognosis.关键词
红斑狼疮,系统性/间质性肺炎/危险因素Key words
lupus erythematosus, systemic/interstitial pneumonia/risk factor分类
医药卫生引用本文复制引用
陈晓芳,杨敏,赵进军,赖伟男,郝鹏..系统性红斑狼疮合并间质性肺炎的临床特征及相关危险因素分析[J].重庆医学,2018,47(11):1460-1464,5.基金项目
国家自然科学基金资助项目(81172875). （81172875）
