重庆医学2018，Vol.47Issue(12)：1599-1602,4.DOI:10.3969/j.issn.1671-8348.2018.12.009
血尿酸对代谢综合征的预测作用研究
Predictive research on serum uric acid to metabolic syndrome
摘要
Abstract
Objective To explore the mutual relationship between serum uric acid (SUA) level with metabolic syndrome (MD) and its factors among the physical examination population.Methods A total of 8 285 people undergoing the physical check-up in a hospital in 2013 were selected by sampling and conducted the physical measurement and biochemical detection;the subjects were grouped according to the MS diagnostic standard,gender and SUA.Then the correlation between SUA and MS was analyzed.Results The age,BMI,SBP,DBP,FPG,TG and SUA in the MS patients were significantly higher than those in the patients without MS,while the HDL-C level was significantly lower.The occurrence rate of MS in males was higher than females.With the increase of MS factors,the SUA level showed the overall rising trend;the multiple stepwise regression analysis indicated that BMI,DBP and TG were positively correlated with SUA,and the HDL-C level was negatively correlated with the SUA level.The regression equation was Y =-2.135 + 0.066X1 +0.010X2 +0.155X3-0.379X4;the MS detection rate in the HUA group was higher than that in the non-HUA group;in the single factor Logistic regression analysis,the SUA level was significantly related with the MS occurrence (OR=1.007,95％CI 0.006-1.007,P＜0.05),in the SUA diagnostic value for M,AUC in male and female were 0.608 (95 ％CI 0.582-0.634,P＜0.01) and 0.744 (95 ％CI 0.705-0.783,P＜0.01) respectively,the MS best critical diagnostic points in male and female were 360.5 and 256.5,the corresponding diagnostic sensitivities in male and female were 46.49％ and 71.94％,the specificities in male and female were 69.94％ and 69.94％ respectively.Conclusion The SUA level is closely associated with MS,and SUA level has a good predictive effect for MS.关键词
尿酸/代谢综合征/回归分析/体检人群/受试者工作特征曲线Key words
uric acid/metabolic syndrome/regression analysis/physical examination population/ROC curve分类
医药卫生引用本文复制引用
张明坤,贾润萍,崔玲玲,叶燕林,孙锦峰,王玲..血尿酸对代谢综合征的预测作用研究[J].重庆医学,2018,47(12):1599-1602,4.基金项目
2012年河南省医学科技攻关计划项目(201204035). （201204035）
