福建农业学报2017，Vol.32Issue(11)：1189-1192,4.DOI:10.19303/j.issn.1008-0384.2017.011.004
新型鸭呼肠孤病毒病浓缩灭活疫苗的制备及免疫原性分析
Efficacy Evaluation of a Concentrated Inactivated Vaccine against Novel Duckling Reovirus Infection
摘要
Abstract
In this paper,an experimental concentrated inactivated vaccine and a conventional inactivated vaccine against Novel Duckling Reovirus (NDRV) infection were prepared.After one single-dose immunization in adult Cherry Valley ducks,the serum samples collected in a period of 13 weeks were tested for antibodies by serum neutralisation (SN) method.The protective effects against NDRV infection were observed in 3-day-old Cherry Valley ducklings and mule duckling after a single-dose immunization.The serological results showed that concentrated inactivated vaccine was much more immunogenic than the conventional inactivated vaccine,with a much higher SN antibody titers at all test time points.The concentrated inactivated vaccine was highly protective against NDRV challenge at 7-day post-vaccination with a 100 ％ protective efficacy,as compared to 40％-60％ protective efficacy for conventional inactivated vaccine.Taken together,this experimental concentrated inactivated vaccine exhibited immune efficiency much superior to conventional inactivated vaccine and might be a useful vaccine against NDRV infection.关键词
新型鸭呼肠孤病毒感染/浓缩疫苗/常规疫苗/免疫原性Key words
Novel Duck Reovirus infection/concentrated inactivated vaccine/conventional inactivated vaccine/efficacy evaluation分类
农业科技引用本文复制引用
陈仕龙,肖世峰,程晓霞,林锋强,王劭,王锦祥,朱小丽,陈少莺..新型鸭呼肠孤病毒病浓缩灭活疫苗的制备及免疫原性分析[J].福建农业学报,2017,32(11):1189-1192,4.基金项目
福建省科技计划项目——省属公益类科研院所基本科研专项(2014R1023-9) （2014R1023-9）
福建省农业科学院青年英才项目(YC2016-1) （YC2016-1）
