国际口腔医学杂志2018，Vol.45Issue(3)：272-275,4.DOI:10.7518/gjkq.2018.03.005
RNA腺嘌呤6-甲基化修饰调控干细胞分化的研究进展
Regulation of RNA N6-methylation of adenosine on stem cell differentiation
摘要
Abstract
N6-methylation of adenosine is the most prevalent post-transcriptional RNA modification in eukaryotes. Mettl3, Mettl14 and Wtap are methyltransferases that catalyse the formation of N6-methyladenosine (m6A). Demethylase, FTO and ALKBH5 can remove the methyl of m6A, thereby rendering a dynamic and reversible m6A modification. Methyltransferases and demethylases can regulate the pluripotency and differentiation of stem cells through writing and erasure of m6A marks on RNA. These data provide a novel dimension in epigenetic regulation at the RNA level to affect stem cell fate.关键词
6-甲基腺嘌呤/甲基转移酶/去甲基化酶/干细胞分化/多能性Key words
N6-methyladenosine/methyltransferase/demethylase/stem cell differentiation/pluripotency分类
生物科学引用本文复制引用
武云舒,袁泉..RNA腺嘌呤6-甲基化修饰调控干细胞分化的研究进展[J].国际口腔医学杂志,2018,45(3):272-275,4.基金项目
国家自然科学基金(81722014) （81722014）
四川省科技创新团队项目(2017TD0016)This study was supported by National Natural Science Foundation of China(81722014)and Sichuan Province Science and Technology Innovation Team Program(2017TD0016). （2017TD0016）
