国际口腔医学杂志2018，Vol.45Issue(3)：286-290,5.DOI:10.7518/gjkq.2018.03.008
Wnt信号通路在调控牙髓干细胞多向分化及炎症损伤修复中的作用
Wnt signaling pathway mediates the dental pulp stem cells in multipotential differentiation and inflammatory microenvironment
摘要
Abstract
Human dental pulp stem cell (hDPSC) and stem cells from human exfoliated deciduous teeth (SHED) are human mesenchymal stem cells demonstrating multipotential differentiation capabilities. The Wnt signaling pathway consists of canonical Wnt/β-catenin and noncanonical Wnt signal pathways, which are activated during tooth morphogenesis. These pathways also play key roles in the dental pulp repair process. During inflammation, an activated Wnt signal pathway plays a significant role in the process involved in the repair of a damaged tooth. This pathway also participates in hDPSC proliferation and odontoblastic differentiation. In non-inflammatory conditions, hDPSC and SHED differentiate into osteoblasts and odontoblasts, respectively, which suppress adipogenic differentiation through the Wnt signaling pathway.关键词
Wnt信号通路/牙髓干细胞/乳牙牙髓干细胞/分化Key words
Wnt signaling pathway/dental pulp stem cell/stem cells from human exfoliated deciduous teeth/differentiation分类
生物科学引用本文复制引用
杨鑫,李思洁,赵玮..Wnt信号通路在调控牙髓干细胞多向分化及炎症损伤修复中的作用[J].国际口腔医学杂志,2018,45(3):286-290,5.基金项目
广东省科技计划项目(2016A020215094) （2016A020215094）
广东省自然科学基金(2014A030313126)This study was supported by Science and Technology Planning Project of Guangdong Province(2016A020215094)and Natural Science Foundation of Guangdong Province(2014A030313126). （2014A030313126）
