海南医学院学报2018，Vol.24Issue(6)：657-660,4.DOI:10.13210/j.cnki.jbmu.20180403.012
急性心肌梗死患者血清miR-208对血小板功能、炎症反应及心肌损伤程度的影响
Effect of serum miR-208 on platelet function,inflammatory response and myocardial injury in patients with acute myocardial infarction
摘要
Abstract
Objective:To study tbe effect of serum miR-208 on platelet function,inflammatory response and myocardial injury in patients witb acute myocardial infarction.Metbods:Patients witb acute myocardial infarction and tbose witb unstable angina pectoris wbo were treated in Ankang Central Hospital between June 2015 and October 2017 were selected as tbe AMI group and UAP group of tbe researcb respectively;tbe bealtby volunteers wbo received pbysical examination in Ankang Central Hospital during tbe same period were selected as tbe control group.Tbe miR-208 expression,platelet parameters,inflammato-ry response cytokines and myocardial injury markers were measured.Results:Serum miR-208 expression,PAF,TGF-β1,IL-10,TNF-α,sICAM1,sVCAM1,Myo,CK-MB,LDH and H-FABP contents as well as platelet surface C3aR,C5aR and GPI-Ib/IIIa expression intensity of AMI group and UAP group were significantly bigber tban tbose of control group(P<0.05), and serum miR-208 expression,PAF,TGF-β1,IL-10,TNF-α,sICAM1,sVCAM1,Myo,CK-MB,LDH and H-FABP con-tents as well as platelet surface C3aR,C5aR and GPIIb/IIIa expression intensity of AMI group were significantly bigber tban tbose of UAP group(P<0.05).Conclusion:Tbe bigb expression of serum miR-208 can aggravate tbe platelet activation,in-flammatory response activation and myocardial injury in patients witb acute myocardial infarction.关键词
急性心肌梗死/miR-208/血小板激活/炎症反应Key words
Acute myocardial infarction/miR-208/Platelet activation/Inflammatory response分类
医药卫生引用本文复制引用
曾德银,刘茜..急性心肌梗死患者血清miR-208对血小板功能、炎症反应及心肌损伤程度的影响[J].海南医学院学报,2018,24(6):657-660,4.基金项目
安康市科技一般项目(16CD0403)This study was supportel by Ankang Municipal Science and Technology General Project(Grant No.16CD0403) （16CD0403）
