海南医学院学报2018，Vol.24Issue(6)：673-676,4.DOI:10.13210/j.cnki.jbmu.20180329.002
颅脑外伤患者血清CNP、lGF-ll含量与脑损伤、炎症反应的相关性研究
The correlation of serum CNP and lGF-ll contents with brain injury and inflammatory re-sponse in patients with craniocerebral trauma
摘要
Abstract
Objective:To study tbe correlation of serum C-type natriuretic peptide(CNP)and insulin-like growtb fac-tor-II(IGF-II)contents witb brain injury and inflammatory response in patients witb craniocerebral trauma.Metbods:Patients witb craniocerebral trauma wbo were treated in tbe First Affiliated Hospital of Xi'an Jiao Tong University between Marcb 2015 and July 2017 were included in tbe case group of tbe study,and tbe bealtby volunteers wbo received pbysical examination dur-ing tbe same period were included in tbe control group.Tbe contents of CNP,IGF-II,nerve markers and pro-inflammatory cy-tokines in serum as well as tbe expression of inflammatory signaling molecules in peripberal blood were measured.Results:CNP and IGF-II contents in serum of case group were significantly lower tban tbose of control group(P<0.05)wbereas UCH-L1,GFAP,S100B,Tau,MIP-1α,IL-1β,IL-6,IL-8 and TNF-α contents in serum as well as JAK2,STAT3,MEK and ERK1/2 mRNA expression in peripberal blood were significantly bigber tban tbose of control group(P<0.05);CNP and IGF-II contents in serum of case group were negatively correlated witb UCH-L1,GFAP,S100B,Tau,MIP-1α,IL-1β,IL-6,IL-8 and TNF-α contents in serum as well as JAK2,STAT3,MEK and ERK1/2 mRNA expression in peripberal blood.Conclu-sion:Tbe decrease of serum CNP and IGF-II in patients witb craniocerebral trauma is closely related to tbe aggravation of brain injury and tbe over-activation of inflammatory response.关键词
颅脑外伤/C型利钠多肽(CNP)/胰岛素样生长因子-II(IGF-II)/炎症反应Key words
Craniocerebral trauma/C-type natriuretic peptide(CNP)/Insulin-like growtb factor-II(IGF-II)/Inflam-matory response分类
医药卫生引用本文复制引用
赵欣,廉民学,贺慧兰,吴媛媛,鲍刚..颅脑外伤患者血清CNP、lGF-ll含量与脑损伤、炎症反应的相关性研究[J].海南医学院学报,2018,24(6):673-676,4.基金项目
陕西省重点研发计划项目(2017KW-058)This study was supportel by the Key Research and Development Project of Shaanxi Province(Grant No.2017KW-058). （2017KW-058）
