海南医学院学报2018，Vol.24Issue(6)：684-687,4.DOI:10.13210/j.cnki.jbmu.20180322.002
双歧杆菌肠内营养对重症脑卒中患者肠道菌群及全身炎症应激程度的影响
Effect of bifidobacterium enteral nutrition on intestinal flora and systemic inflammatory stress in patients with severe stroke
摘要
Abstract
Objective:To study tbe effect of bifidobacterium enteral nutrition on intestinal flora and systemic inflamma-tory stress in patients witb severe stroke.Metbods:Patients witb severe stroke wbo were treated in our bospital between Marcb 2015 and July 2017 were selected and randomly divided into tbe observation group wbo accepted bifidobacterium enteral nutrition and tbe control group wbo accepted conventional enteral nutrition,and tbe contents of intestinal flora in feces as well as tbe contents of intestinal mucosal barrier markers,inflammatory response indexes,stress response indexes in serum were determined.Results:D-lactic acid,DAO,PCT,Claudin-4,TNF-α,IL-1β,Hcy,sICAM1,NE,Cor and MDA contents in se-rum of botb groups 14 days after treatment were lower tban tbose before treatment wbereas T-AOC contents were bigber tban tbose before treatment,and bifidobacterium,lactobacillus and bacteroides contents in feces as well as T-AOC content in serum of observation group 14 days after treatment were bigber tban tbose of control group wbereas enterococcus and enterobacter contents in feces as well as D-lactic acid,DAO,PCT,Claudin-4,TNF-α,IL-1β,Hcy,sICAM1,NE,Cor and MDA contents in serum were lower tban tbose of control group.Conclusion:Bifidobacterium enteral nutrition is able to improve tbe intestinal flora and suppress tbe systemic inflammatory stress in patients witb severe stroke.关键词
重症脑卒中/双歧杆菌/肠道菌群/炎症反应/应激反应Key words
severe stroke/bifidobacterium/intestinal flora/inflammatory response/stress response分类
医药卫生引用本文复制引用
谭贞..双歧杆菌肠内营养对重症脑卒中患者肠道菌群及全身炎症应激程度的影响[J].海南医学院学报,2018,24(6):684-687,4.基金项目
四川省卫计委科研课题(150749)It is supportel by Scientific Research Project of Sichuan Provincial Health and Family Planing Commission(150749). （150749）
