海南医学院学报2018，Vol.24Issue(7)：807-810,4.DOI:10.13210/j.cnki.jhmu.20180403.004
阿托伐他汀联合氯吡格雷治疗对急性脑梗死患者炎症因子、凝血功能及血小板活化的影响研究
Effect of atorvastatin and clopidogrel on inflammatory factors,blood coagulation and platelet activation in patients with acute cerebral infarction
摘要
Abstract
Objective:To investigate the effects of atorvastatin combined with clopidogrel on inflammatory factors,co-agulation and platelet activation in patients with acute cerebral infarction.Methods:140 cases patients with acute cerebral in-farction who were confirmed by clinical and imaging diagnoses were randomly divided into treatment group(70 cases)and con-trol group(70 cases).Both groups were treated routinely before treatment.The observation group was treated with clopidogrel and atorvastatin,while the control group was treated with aspirin and atorvastatin.The changes of inflammatory factors,coag-ulation function and platelet activation index before and after treatment were compared between the two groups.Result:Before treatment,the levels of serum soluble intercellular adhesion molecule-1(sICAM-1),transforming growth factor-β(TGF-β), coagulation parameters prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),coagulation index of platelets platelet α-membrane glycoprotein(CD62p),lysosomal granular membrane glycoprotein(CD63),platelet-monocyte aggregates(PMA),coagulation parameters were not statistically significant(P>0.05).After treatment,the levels of sICAM-1,CD62p,CD63,PMA and FIB in both groups decreased and the levels of TGF-β,PT and APTT increased.The levels of sICAM-1,FIB,CD62p,CD63 and PMA in the observation group were(370.32 ± 37.13)ng/mL,(1.97 ± 0.21)g/L,(1.38 ± 0.14)%,(0.22 ± 0.02)%,and(18.47+ 1.85)% respectively,which were lower than those in the control group [(410.47±42.32)ng/mL,(2.58±0.26)s,(2.67 ± 0.27)%,(0.35 ± 0.03)% and(22.87 ± 2.91)%].While the levels of TGF-β,PT and APPT were(231.53 ± 23. 52)ng/mL,(15.42 ± 1.53)s,(37.31 ± 3.54)s were higher than the control group[(218.56 ± 22.17)ng/mL,(12.32 ± 1.27)s and(29.89 ± 3.01)s]. And the differences were significant(P<0.05).Conclusion:Atorvastatin combined with clopidogrel treatment can effectively relieve the inflammatory response,reduce the release of inflammatory cytokines,improve blood coagulation and inhibit platelet aggregation in patients with acute cerebral infarction.So it deserves further clinical promotion.关键词
氯吡格雷/急性脑梗死/炎症因子/凝血功能/血小板活化功能Key words
clopidogrel/acute cerebral infarction/inflammatory factors/coagulation/platelet activation分类
医药卫生引用本文复制引用
李爽,陈娟,刘科..阿托伐他汀联合氯吡格雷治疗对急性脑梗死患者炎症因子、凝血功能及血小板活化的影响研究[J].海南医学院学报,2018,24(7):807-810,4.基金项目
河北省邢台市科技支撑计划项目(2014ZC154)It is supported by Scientific Technology Supporting Plan Project of Xingtai City in Hebei Province(2014ZC154)． （2014ZC154）
