湖南中医药大学学报2018，Vol.38Issue(4)：365-371,7.DOI:10.3969/j.issn.1674-070X.2018.04.001
自发性高血压大鼠左心室肥厚的代谢组学研究
Metabonomics Study of Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats
摘要
Abstract
Objective To investigate the changes of small molecular products in left ventricular hypertrophyof spontaneously hypertensive rats (SHR), the Wistar rats with normal pressure as the control group. Methods The metabolites were detected by gas chromatography-mass spectrometry (GC-MS), and the differences of metabolite were analyzed by partial least squares (partial least squares discriminant analysis, PLS-DA). According to the variable importance (VIP) and independent variable coefficients, the left ventricular hypertrophy and myocardial age products in SHR rats were investigated. Results SHR group was positively correlated with: 90 squalene, 51 terephthalic acid, 87 maltose, 68 palmitoleic acid, 77 glucose-6-phosphate 1, 8 2-hydroxybutyric acid, 78 unknown, 74 oleic acid, 56 fructose 1, 28 three cyanogens alanine. Negative related with: 21 succinate, 24 fumarate, 2 pyruvic acid, 34 aspartic acid 1, 85 unknown, 45unknown, 88 glycerol ester of single oil, 86 olein. Conclusion It is further confirmed that the left ventricular hypertrophy induced by hypertension is closely related to the destruction of myocardial cell structure and the imbalance of energy.关键词
SHR/左心室肥厚/代谢组学Key words
SHR/left ventricular hypertrophy/metabonomics分类
医药卫生引用本文复制引用
简维雄,肖隋熙,刘培,罗颖,陈偶英,冯宇,王健章,谭元生..自发性高血压大鼠左心室肥厚的代谢组学研究[J].湖南中医药大学学报,2018,38(4):365-371,7.基金项目
国家自然科学基金项目(81774207 （）
81202647 （）
81473616) （）
中医诊断国家重点学科开放项目(2014-16). （2014-16）
