湖南中医药大学学报2018，Vol.38Issue(4)：384-388,5.DOI:10.3969/j.issn.1674-070X.2018.04.005
锌-α2-糖蛋白在高尿酸血症模型小鼠肾脏中表达的变化
Expression of Zinc-α2-glycoprote in the Kidney of Mice with Hyperuricemia
摘要
Abstract
Objective To explore the correlation between serum uric acid and kidney zinc-α2-glycoprotein (ZAG) in hyper uricemia mice model, in order to seek a new potential target for prevention and treatment of hyperuricemia. Methods 20 SPF Kunming mice were randomly divided into hyperuricemia model group and control group, 97 % sylvite acid potassium salt of 0.5 g/(kg·d) was injected into the abdominal cavity. The hyperuricemia mice model was confirmed by the serum uric acid (SUA) level 7 days later. The levels of ZAG mRNA and protein were detected by Western blotting and real-time fluorescence quantitative. Results Compared with the blank group, the levels of ZAG mRNA and protein in the kidney tissue in the model group increased, the difference was statistically significant (P<0.05). Conclusion Serum uric acid may affect the level of ZAG, and the correlation mechanism between ZAG and uric acid needs to be further explored.关键词
锌-α2-糖蛋白/高尿酸血症/肾脏/小鼠Key words
zinc-α2-glycoprotein/hyperuricemia/kidney/mice分类
医药卫生引用本文复制引用
刘李玟韬,杨洁,陈秉朴..锌-α2-糖蛋白在高尿酸血症模型小鼠肾脏中表达的变化[J].湖南中医药大学学报,2018,38(4):384-388,5.基金项目
广西高校科学技术研究项目(ZD2014105) （ZD2014105）
广西高校少数民族人类学重点研究室项目[桂教科研(2015)5号]. （2015）
