湖南中医药大学学报2018，Vol.38Issue(4)：393-396,4.DOI:10.3969/j.issn.1674-070X.2018.04.007
强心安神汤对慢性心衰大鼠AngⅡ及AT1mRNA表达的影响
Effects of Qiangxin Anshen Decoction on the Expression of AngⅡ and AT1 mRNA in Rats with Chronic Heart Failure
摘要
Abstract
Objective To study the effect of Qiangxin Anshen decoction on the expression of AngⅡand AT1 mRNA in the model of Wistar rats with chronic heart failure, and investigate its possible mechanism. Methods Except for the blank group, the model rats were randomly divided into model group, Western medicine group, high-dose Qiangxin Anshen decoction group and low-dose Qiangxin Anshen decoction group. After intervention treatment for 4 weeks, the content of AngⅡof serum in rats was measured. The rats were killed and the AT1 mRNA expression in myocardial tissues were detected. Results Compared with the model and Western medicine groups,the content of AngⅡ in the rats serum and AT1 mRNA expression of myocardial tissues in Qiangxin Anshen decoction group was statistically significant (P﹤0.05 or P<0.01), Conclusion The mechanism of Qiangxin Anshen decoction in treating heart failure may be related with the up-regulation of AT1 mRNA expression caused by restraining Ang II.关键词
慢性心衰/强心安神汤/AngⅡ/AT1mRNAKey words
chronic congestive heart failure/Qiangxin Anshen decoction/AngⅡ/AT1 mRNA分类
医药卫生引用本文复制引用
颜旭,刘春华,庄红,陈琪,张婷,赵启,蔡雷..强心安神汤对慢性心衰大鼠AngⅡ及AT1mRNA表达的影响[J].湖南中医药大学学报,2018,38(4):393-396,4.基金项目
湖南省教育厅资助(09C740) （09C740）
湖南省卫生厅中医药科研基金(2009038). （2009038）
