湖南中医药大学学报2018，Vol.38Issue(4)：459-462,4.DOI:10.3969/j.issn.1674-070X.2018.04.024
温肾健脾方对重症肌无力患者免疫功能的影响
Effect of Wenshen Jianpi Decoction on the Immunologic Function in Patients with Myasthenia Gravis
摘要
Abstract
Objective To observe the effect of Wenshen Jianpi decoction on the immunologic function in spleen-kidney yang deficiency patients with myasthenia gravis. Methods 18 MG patients with spleen-kidney yang deficiency were selected as observation group and 20 healthy subjects were selected as normal control group in the same period. The levels of BAFF and IL-6 were measured by ELISA and the percentage of B lymphocyte subsets in peripheral blood was detected by flow cytometry before and after treatment. Results The expression of IL-6,BAFF in MG patients were significantly higher than the normal control group (P<0.01). After Wenshen Jianpi decoction treatment for 1 month, the levels of IL-6 and BAFF in MG patients decreased significantly (P<0.01). The percentage of CD19+CD27+cells before and after treatment were (1.04±0.24)%, 0.96± 0.28)%, the percentage of CD19+CD27-cells before and after treatment were (3.02±1.12)%,(2.12±0.42)%, the differences were ststistically significant (P<0.05). Conclusion Wenshen Jianpi decoction has exact effects on immune regulation in patients with myasthenia gravis,and the mechanism may be related to reducing the number of undifferentiated B lymphocytes and the levels of BAFF and IL-6 in peripheral blood.关键词
重症肌无力/温肾健脾方/B淋巴细胞亚群/IL-6/BAFFKey words
myasthenia gravis/Wenshen Jianpi decoction/B lymphocyte subsets/IL-6/BAFF分类
医药卫生引用本文复制引用
张丽香,郭全,郭远瑾,韦俊杰,李吕力,钟维章,蔺心敬,李燕华,李晓峰..温肾健脾方对重症肌无力患者免疫功能的影响[J].湖南中医药大学学报,2018,38(4):459-462,4.基金项目
广西中医药科技重点项目(GZKZ10-012). （GZKZ10-012）
