兰州大学学报（医学版）2018，Vol.44Issue(2)：54-58,5.DOI:10.13885/j.issn.1000-2812.2018.02.009
应用凝血标志物诊断肺癌患者血栓前状态的病例对照
Blood coagulation biomarkers for prethrombotic state diagnosis in lung cancer patients: a case control study
摘要
Abstract
Objective To evaluate coagulation markers in patients with lung cancer changes,analyze their value in the diagnosis of prethrombotic state.Methods 61 patients with primary lung cancer,61 patients with benign lung disease and 61 healthy controls were selected as lung cancer group,benign lung disease group and healthy control group respectively.Chemiluminescent immunoassay was used to detect the plasma levels of thrombomodulin (TM),thrombin-antithrombin Ⅲ complex (TAT),tissue plasminogen activator-plasmino gen activatorinhibitor-1 complex (t-PAIC) and plasmin-α2 plasmin inhibitor complex (PIC),and immunofluo rescence was used to detect D-dimer content.Results Plasma levels of TM and TAT in lung cancer group were significantly higher than those in benign lung disease group (P＜ 0.05).Compared with healthy controls,plasma levels of TM,TAT,t-PAIC and PIC in lung cancer group were significantly increased (P ＜ 0.05).Compared with healthy control group,plasma t-PAIC and D-dimer levels were significantly increased in patients with benign lung diseases (P ＜ 0.05).The differences of TM,PIC,D-dimer levels in different pathological types of lung cancer were statistically significant.Conclusion There were coagulation and fibrinolytic system abnormalities in patients with lung cancer.关键词
肺癌/血栓前状态/血栓调节蛋白/组织型纤溶酶原激活物/纤维蛋白原降解物Key words
lung cancer/prethrombotic state/thrombomodulin/tissue plasminogen activator/fibrin fibrinogen degradation products分类
医药卫生引用本文复制引用
张蕾,谭榜云,孙志鹏,卢大鹏,安淑娟,陈琳,张巧梅,李燕平..应用凝血标志物诊断肺癌患者血栓前状态的病例对照[J].兰州大学学报（医学版）,2018,44(2):54-58,5.基金项目
甘肃省青年科技基金项目(1606RJYA266) （1606RJYA266）
