国际眼科杂志2018，Vol.18Issue(5)：862-865,4.DOI:10.3980/j.issn.1672-5123.2018.5.23
玻璃体腔注射康柏西普联合小梁切除术及全视网膜光凝治疗新生血管性青光眼
Intravitreal injection of Conbercept combined with trabeculectomy and panretinal photocoagulation for the treatment of neovascular glaucoma
鱼喆 1蒲晓莉 1延新年 1范强 1张萌 1秦玲利1
作者信息
- 1. 712000 中国陕西省咸阳市第一人民医院眼科
- 折叠
摘要
Abstract
AIM: To investigate the clinical efficacy of intravitreal injection of Conbercept combined with trabeculectomy and panretinal photocoagulation for the treatment of neovascular glaucoma (NVG). METHODS: The clinical data of 90 patients with NVG treated in our hospital from June 2014 to June 2016 were analyzed retrospectively. There were 42 patients treated with trabeculectomy and panretinal photocoagulation enrolled as the control group. On the basis of this, 48 patients who received intravitreal injection of conbercept 5-7d preoperatively were enrolled as observation group. The best corrected visual acuity (standard logarithmic visual acuity), intraocular pressure and the regression of neovascularization were observed and compared before treatment,and 1wk,1,3,and 6mo post treatment. Then the clinical efficacy and postoperative complications were observed and recorded. RESULTS: The difference of visual acuity of the two groups was significant before and after treatment,and the best corrected visual acuity of observation group was significantly higher than that of the control group at 1mo after the operation (P<0.05), no difference was found at 1wk,3 and 6mo post treatment (P>0.05). The pre- and postoperative intraocular pressure of the two groups showed significant difference, and the intraocular pressure of the observation group was significantly lower than the control group at 1wk, 1, 3 and 6mo post treatment (P<0. 05). The cure rate in the observation group was significantly higher than that in the control group (77% vs 64%), with statistical significance (P<0 05). The incidence of anterior chamber hemorrhage and shallow anterior chamber in the observation group was significantly lower than that of the control group (P<0.05), with no difference in the incidence of macular degeneration(P>0.05). Moreover, the recurrence rate of neovascularization in the observation group was significantly lower than that of the control group at 6mo after operation (P<0.05). CONCLUSION: The intravitreal injection of conbercept 5-7d before panretinal photocoagulation can significantly reduce intraocular pressure,improve the visual acuity for the treatment of NVG, which also has a higher comprehensive cure rate.关键词
玻璃体腔/康柏西普/全视网膜光凝/新生血管性青光眼Key words
intravitreal injection/conbercept/panretinal photocoagulation/neovascular glaucoma引用本文复制引用
鱼喆,蒲晓莉,延新年,范强,张萌,秦玲利..玻璃体腔注射康柏西普联合小梁切除术及全视网膜光凝治疗新生血管性青光眼[J].国际眼科杂志,2018,18(5):862-865,4.
