国际眼科杂志2018，Vol.18Issue(5)：866-868,3.DOI:10.3980/j.issn.1672-5123.2018.5.24
β1肾上腺素受体R389G基因多态性与POAG患者眼压变化的关系
Relationship between polymorphism of beta 1 adrenergic receptor R389G gene and intraocular pressure in patients with POAG
王莹 1周文娟 1张艳1
作者信息
- 1. 617097 中国四川省攀枝花市,攀枝花学院附属医院攀枝花市中西医结合医院眼科
- 折叠
摘要
Abstract
AIM:To investigate the relationship between adrenergic receptor(AR) R389G gene polymorphism and changes in intraocular pressure in patients with primary open angle glaucoma (POAG). METHODS: We selected 100 patients with newly diagnosed POAG from January 2015 to February 2017 in our hospital. The patient's intraocular pressure was measured at 6:00, 12:00, 18:00, and 24:00 daily and the mean value was calculated. Patients with mean intraocular pressure >30mmHg were included in Group A (44 patients), patients with mean intraocular pressure <30mmHg were treated as Group B (56 patients). The clinical data of two groups of patients were compared, and multivariate Logistic regression analysis was used to investigate the relationship between β1AR R389G gene polymorphism and changes in intraocular pressure in patients with POAG. RESULTS: The frequency of GG genotype in Group A (27.3%) was significantly higher than that in Group B (8 9%) (P < 0. 05). The allele G frequency was significantly higher in Group A (40.9%) than in Group B (18.8%), with a statistically significant difference (P<0 05). By multivariate Logistic regression analysis, increased systolic blood pressure and increased frequency of β1AR R389G allele were independent risk factors for increased intraocular pressure in POAG patients (P <0 05). CONCLUSION: The β1AR R389G gene polymorphism is closely related to POAG and is an independent risk factor for increased intraocular pressure in patients with POAG.关键词
茁1肾上腺素受体/基因多态性/原发性开角型青光眼/眼压Key words
β1 adrenergic receptor/gene polymorphism/primary open angle glaucoma/intraocular pressure引用本文复制引用
王莹,周文娟,张艳..β1肾上腺素受体R389G基因多态性与POAG患者眼压变化的关系[J].国际眼科杂志,2018,18(5):866-868,3.
