实用肝脏病杂志2018，Vol.21Issue(3)：340-343,4.DOI:10.3969/j.issn.1672-5069.2018.03.006
复方鳖甲软肝片联合丁二磺酸腺苷蛋氨酸和熊去氧胆酸治疗PBC患者疗效及其对血清肝纤维化指标的影响
Efficacy of Fufangbiejia Ruanganpian and ursodeoxycholic acid combination in the treatment of patients with primary biliary cirrhosis
摘要
Abstract
Objective To investigate the efficacy of Fufangbiejia Ruanganpian,a herbal compound,and ursodeoxycholic acid(UDCA)combination in the treatment of patients with primary biliary cirrhosis(PBC). Methods 64 patients with PBC were recruited in this study between September 2012 and September 2016,and they were randomly divided into two groups by computer-generated numbers. The patients in observation group received Fufangbiejia Ruanganpian,succinic acid adenosine methionine,and UDCA,and the patients in the control received all but the herbal compound medicines. Serum hyaluronic acid(HA),laminin(LN),procollagen Ⅲ N terminal peptide(PC-III)and type fore collagen(IV-C)levels were detected routinely and life quality was estimated by GQOL-74. Results At the end of observation,serum ALT,AST and TBIL levels in the combination group were(54.4±15.)U/L,(61.3±16.4)U/L and(23.7±9.5)μmol/L,significantly lower than(70.3±16.1)U/L,(75.5± 16.5)U/L and(36.8±9.7)μmol/L in the control(P<0.05);serum HA,LN,PC-III and IV-C levels were(116.9± 12.5)μg/L,(103.4±11.4)μg/L,(123.6±22.8)μg/L and(80.4±9.8)μg/L,significantly lower than(156.5±12.7)μg/L,(126.9 ±11.2)μg/L,(155.5 ±22.4)μg/L and(97.6 ±9.9)μg/L in the control(P<0.05);the physical function, psychological function,social function and material life scores were(78.9±8.6),(80.8±7.5),(89.7±9.7)and(83.7± 9.3), significantly higher than(69.7 ±8.3),(71.9 ±7.6),(79.7 ±9.5)and(75.2 ±9.2)in the control(P<0.05). Conclusion The combination of the Chinese herbal compound and adenosine methionine as well as UDCA in treatment of patients with PBC is effective,which might improve the liver functions,reduce serum HA,LN,PC-III and IV-C levels,and improve the quality of life.关键词
原发性胆汁性肝硬化/复方鳖甲软肝片/丁二磺酸腺苷蛋氨酸/熊去氧胆酸/治疗Key words
Primary biliary cirrhosis/Fufangbiejia Ruanganpian/a herbal medicine/Metionine/Ursodeoxycholic acid/Therapy引用本文复制引用
刘进国,王暴魁..复方鳖甲软肝片联合丁二磺酸腺苷蛋氨酸和熊去氧胆酸治疗PBC患者疗效及其对血清肝纤维化指标的影响[J].实用肝脏病杂志,2018,21(3):340-343,4.基金项目
漯河市科技局医药科技计划项目(编号:201504377) （编号:201504377）
