实用肝脏病杂志2018，Vol.21Issue(3)：401-404,4.DOI:10.3969/j.issn.1672-5069.2018.03.021
慢性丙型肝炎外周血miR-1273g-3p水平变化及其诊断肝纤维化分期的效能分析
Efficacy of serum miR-1273g-3p levels in diagnosis of liver fibrosis in patients with chronic hepatitis C
摘要
Abstract
Objective To explore the efficacy of serum miR-1273g-3p levels in diagnosis of liver fibrosis in patients with chronic hepatitis C(CHC). Methods 57 patients with CHC and 21 healthy persons were recruited in our hospital,and serum miR-1273g-3p were detected by real-time polymerase chain reaction. The patients with CHC received standardized peg-interferon-α2b and ribavirin therapy for 12 months,and received liver biopsies before and after the regimen. Results Serum miR-1273g-3p levels were(1.02±0.3)in 13 CHC patients with liver fibrosis 0(F0),(1.68±0.26)in 20 with F 1-2,and(4.21±0.42)in 24 with F 3-4,respectively, which suggested serum miR-1273g-3p levels in patients with liver fibrosis were much higher than [(1.03±0.2), P<0.05]in healthy persons or in patients without;at the end of the regimen,serum miR-1273g-3p levels in patients with CHC F0,F1-2 and F3-4 were(1.03±0.4),(1.43±0.22)and(3.97±0.2),respectively,much lower than those before anti-viral treatment(P<0.05);the AUC of serum miR-1273g-3p levels in diagnosing liver fibrosis and significant liver fibrosis were 0.830,95%CI 为0.714~0.973(sensitivity 72.2% and specificity 86.4%),and were 0.864,95%CI为0.701~0.976(sensitivity 83.6% and specificity 78.4%,as the cut-off-value were >1.68 and>4.20,respectively;at discontinuation of the regimen,the liver histological examination showed that the liver fibrosis was F0 in 15,F1 in 9,F2 in 14,F3 in 11 and F4 in 8. Conclusions Serum miR-1273g-3p levels might be used to diagnose liver fibrosis in patients with CHC,which warrants further investigation.关键词
慢性丙型肝炎/肝纤维化/血清miR-1273g-3p/诊断Key words
Hepatitis C/miR-1273g-3p/Liver fibrosis/Diagnosis引用本文复制引用
王婧婧,张瑜,董娜,韩振坤,翟景明..慢性丙型肝炎外周血miR-1273g-3p水平变化及其诊断肝纤维化分期的效能分析[J].实用肝脏病杂志,2018,21(3):401-404,4.基金项目
河南省科技计划项目(编号:152102310406) （编号:152102310406）
