实用肝脏病杂志2018，Vol.21Issue(3)：413-416,4.DOI:10.3969/j.issn.1672-5069.2018.03.024
血糖和总胆固醇水平对肝衰竭患者预后的影响
Blood glucose and total cholesterol in the prognosis of patients with liver failure
摘要
Abstract
Objective To analyze blood glucose and total cholesterol(TC)in the prognosis of patients with liver failure(LF). Methods A retrospective analysis was performed on 106 LF patients who were admitted to in our hospital. The patients were divided into blood TC≤1.0 mmol/L group(n=8),1.0 mmol/L<TC≤2.0 mmol/L group(n=49)and TC>2.0 mmol/L group(n=49)according to the TC level at admission. After excluding 10 patients with diabetes,96 patients were divided into normal blood glucose group(n=60),hyperglycemia group(n=12)and hypoglycemia group(n=24)according to the blood glucose levels at admission. The correlation between blood glucose or TC and survival rate was compared respectively. TC was dynamically monitored in 81 patients with TC>1.0 mmol/L at admission to explore the relationship between the dynamic changes of TC and the prognosis of patients with LF. Results Hepatitis B virus(HBV)infection was the main cause of LF in the 106 patients,accounting for 66.0% and the proportion of chronic liver failure(CLF)accounted for 46.2%;the survival rate in patients with hypoglycemia at admission was 41.7%,significantly lower than that in patients with normal blood glucose(71.7%,P<0.01);there were significant differences in survival rates between patients with blood TC≤1.0 mmol/L group,1.0 mmol/L<TC≤2.0 mmol/L group and TC>2.0 mmol/L group and the lower the baseline TC levels,the lower the survival rates(12.5% vs. 51.0% vs. 75.5%,respectively,P<0.05 for all);the survival rate in patients with a declining levels of TC during hospitalization was 28.6%,significantly lower than that in patients with an increasing trend(93.5%,P<0.05). Conclusion Hypoglycemia and blood TC≤2.0 mmol/L at admission or decreased TC level trend are associated with poor prognosis of patients with LF,especially in patients with blood TC≤1.0 mmol/L at admission.关键词
肝衰竭/血糖/总胆固醇/预后Key words
Liver failure/Blood glucose/Total cholesterol/Prognosis引用本文复制引用
吴凤萍,李亚萍,杨颖,石娟娟,李梅,王文俊,党双锁..血糖和总胆固醇水平对肝衰竭患者预后的影响[J].实用肝脏病杂志,2018,21(3):413-416,4.基金项目
国家自然科学基金资助项目(编号:81170393) （编号:81170393）
