中国组织工程研究2018，Vol.22Issue(10)：1586-1592,7.DOI:10.3969/j.issn.2095-4344.0720
β折叠型自组装短肽水凝胶特性及在神经组织工程中的应用前景
The application of beta-sheet self-assembling peptide hydrogels in neural tissue engineering
摘要
Abstract
BACKGROUND: Self-assembling peptides, which allow for an optimal control over the scaffold structure and composition, are described as the innovative tissue-engineered scaffolds in the field of biological medicine. OBJECTIVE: To summarize the biological features of β-sheet self-assembling peptides and current research progress in the neural tissue engineering. METHODS: We took "β sheet, self-assembling peptide, hydrogel, neural stem cell, neural tissue engineering" as the key words in Chinese and English, respectively, to retrieve the related literatures (2000-2017) from PubMed, CNKI, WanFang databases based on internet search. RESULTS AND CONCLUSION: β-sheet self-assembling peptide, designed to function as an engineered mimic of the extra-cellular matrix (ECM), may be used with as a medium to direct growth and axonal connection, promoting neural stem cells adhesion, migration, division, outgrowth, neurogenesis and synaptogenesis. The self-assembling peptides RADA16, LDLK12, QL6 and their functionalized sequences have been proven to be of good utility. As the excellent performance of inducing peripheral nerve regeneration, mediating spinal cord injury and attenuating neuroinflammation, β-sheet self-assembling peptides have promising applications in the neural tissue engineering.关键词
β折叠/自组装短肽/水凝胶/神经干细胞/神经组织工程/生物材料分类
医药卫生引用本文复制引用
卫巍,刘燕飞,何洋,张玲..β折叠型自组装短肽水凝胶特性及在神经组织工程中的应用前景[J].中国组织工程研究,2018,22(10):1586-1592,7.基金项目
贵州省联合资金资助项目(黔科合J字LKZ[2013]01号) （黔科合J字LKZ[2013]01号）
贵州省教育厅自然科学研究项目(黔教合KY字[2015]418) the Key Project of Guizhou Provincial Science and Technology Department,No.LKZ[2013]01 （黔教合KY字[2015]418）
the Natural Science Research Project of Education Department of Guizhou Province,No.[2015]418 （）
