西南国防医药2018，Vol.28Issue(4)：323-326,4.DOI:10.3969/j.issn.1004-0188.2018.04.009
高渗氯化钠液对重型颅脑损伤患者脑氧代谢的影响
Impact of hypertonic sodium chloride solution on cerebral oxygen metabolism of patients with severe craniocerebral injury
刘杰 1李青松 1温韬雪 1李彦 1尚翠翠1
作者信息
- 1. 150001哈尔滨,哈尔滨医科大学附属第二医院神经外科
- 折叠
摘要
Abstract
Objective To observe the impacts of sodium chloride solutions of different concentrations on cerebral oxygen metabolism of the patients with heavy craniocerebral injury.Methods A total of 96 patients with severe traumatic craniocerebral injury were randomly divided into three groups:the control group,the 3％ NaCl group and the high 7.5％ NaCl group (n=32,respectively).On the third and fifth day of treatment,the contents of serum S-100β,neuron-specific enolase (NSE),superoxide dismutase (SOD) and malonaldehyde (MDA) as well as the levels of surplus pulse O2 (SjvO2),regional oxygen saturation (rScO2) and internal jugular vein lactic acid (DjvLac) were compared.Results In comparison with the first day of treatment,on the third and fifth days of treatment,the contents of S-100β,NSE and MDA dropped significantly in all groups (P＜ 0.05) while SOD content increased considerably (P ＜ 0.05);in comparison with the control group,the contents of S-100β,NSE and MDA dropped significantly in the NaCl groups at all the time nodes (P ＜ 0.05) while SOD content increased considerably (P ＜ 0.05);in comparison with the 3％ NaCl group,the high 7.5％ NaC1 group showed significantly decreased contents of S-100β,NSE and MDA at the time nodes (P ＜ 0.05) while SOD content increased considerably (P ＜ 0.05).On the third and fifth days of treatment,SjvO2 level increased greatly in comparison with that in all groups on the first day (P ＜ 0.05) while DjvLac level decreased greatly in comparison with that on the first day.No significant differences were found among the groups (P ＞ 0.05).Conclusion Treating patients with severe craniocerebral injury with 7.5％ NaCl solution can effectively lower serum S-100β and NSE levels,improve cerebral metabolism,relieve cerebral edema and reduce secondary cerebral injury of patients.关键词
高渗/氯化钠液/颅脑/损伤/脑氧代谢Key words
hypertonic/NaCl solution/craniocerebral/injury/cerebral oxygen metabolism分类
医药卫生引用本文复制引用
刘杰,李青松,温韬雪,李彦,尚翠翠..高渗氯化钠液对重型颅脑损伤患者脑氧代谢的影响[J].西南国防医药,2018,28(4):323-326,4.
