西南国防医药2018，Vol.28Issue(4)：334-337,4.DOI:10.3969/j.issn.1004-0188.2018.04.013
氟西汀对抑郁症患者认知记忆功能及ERP-P300的影响
Impact of fluoxetine on cognition & memory functions of patients with depression and on ERP-P300
韩兴玲 1王惠玲2
作者信息
- 1. 430023武汉,武汉大学精神卫生院
- 2. 武汉市优抚医院心理二科
- 折叠
摘要
Abstract
Objective To explore the impacts of fluoxetine on cognition & memory functions of patients with depression and on event-related potential P300 (ERP-P300).Methods A total of 72 patients with depression admitted into our hospital were randomly divided into a fluoxetine group and a control group (n=36,respectively).Both groups received the conventional treatment of the Department of Neurology,and on the basis of this,the fluoxetine group received fluoxetine treatment additionally.Comparisons were made on the HAMD scores,WMS-RC scores and ERP-300 of the groups separately before the treatment and after two and six weeks' treatment.Reaults After Two and six weeks' treatment,the HAMD scores of both groups witnessed a significant decrease (P ＜ 0.05) and the scores of the fluoxetine group were lower than those of the control group.According to the comparison,the WMS-RC scores of both groups appeared to be increasing (P ＜ 0.05),and the scores of the fluoxetine group were higher than those of the control group.The patients' short-term memory after two weeks' fluoxetine treatment and the memory quotient (MQ) after six weeks' fluoxetine treatment were significantly higher than those of the control group during the same period (P ＜ 0.05).After two and six weeks' treatment,P2,N2 and P3 incubation periods of the fluoxetine group were shortened considerably (P ＜ 0.05) while P2 and N2 volatility showed a progressive rise (P ＜ 0.05),which was significantly different from the control group (P ＜ 0.05).No significant change in P3 volatility was observed (P ＞ 0.05).ERP-P300 of the control group did not show a major change during the treatment period (P ＞ 0.05).Conclusion Fluoxetine can effectively improve cognition & memory functions of the patients with depression,of which the mechanism of action may be related to the regulation of ERP-P300 of the patient.关键词
氟西汀/认知/记忆/抑郁症/相关事件电位Key words
fluoxetine/cognition/memory/depression/ERP分类
医药卫生引用本文复制引用
韩兴玲,王惠玲..氟西汀对抑郁症患者认知记忆功能及ERP-P300的影响[J].西南国防医药,2018,28(4):334-337,4.
