中国当代儿科杂志2018，Vol.20Issue(4)：295-297,3.DOI:10.7499/j.issn.1008-8830.2018.04.008
儿童恶性肿瘤相关性噬血细胞综合征24例临床分析
Clinical features and prognosis of malignancy-associated hemophagocytic lymphohistiocytosis in children: a clinical analysis of 24 cases
张婉妍 1张园 1董南南 1王颖超 1盛光耀 1徐学聚 1刘玉峰1
作者信息
- 1. 郑州大学第一附属医院儿童医院血液肿瘤科,河南郑州450052
- 折叠
摘要
Abstract
Objective To investigate the clinical features and prognosis of malignancy-associated hemophagocytic lymphohistiocytosis (MAHS) in children.Methods A retrospective analysis was performed for the primary diseases,clinical features,and prognosis of 24 children with MAHS.Results Among the 24 children,11 (46％) had MAHS induced by tumor and 13 (54％) had chemotherapy-associated MAHS.As for primary diseases,17 children had acute leukemia,6 had lymphoma,and 1 had neuroblastoma.The most common clinical manifestations were pyrexia,respiratory symptoms,and hepatosplenomegaly.The most common laboratory abnormalities were hemocytopenia,elevated serum ferritin,and elevated lactate dehydrogenase.Of the 24 children,22 were treated according to the HLH-2004 protocol and 2 gave up treatment;18 children died,1 was lost to follow-up,and 5 survived.The survival time ranged from 3 days to 2 years and 4 months (median 28 days).Conclusions Children with MAHS have various clinical features and extremely poor treatment outcomes.关键词
恶性肿瘤相关性噬血细胞综合征/急性白血病/淋巴瘤/儿童Key words
Malignancy-associated hemophagocytic lymphohistiocytosis/Acute leukemia/Lymphoma/Child引用本文复制引用
张婉妍,张园,董南南,王颖超,盛光耀,徐学聚,刘玉峰..儿童恶性肿瘤相关性噬血细胞综合征24例临床分析[J].中国当代儿科杂志,2018,20(4):295-297,3.
