中国当代儿科杂志2018，Vol.20Issue(4)：326-331,6.DOI:10.7499/j.issn.1008-8830.2018.04.014
少突胶质前体细胞移植对早产儿脑白质损伤的保护作用
Neuroprotective effects of oligodendrocyte precursor cells on white matter damage in preterm infants
摘要
Abstract
White matter damage,characterized by demyelination due to the damage of oligodendrocyte precursor cells (OPCs),is the most common type of brain damage in preterm infants.Survivors are often subject to long-term neurodevelopmental sequelae because of the lack of effective treatment.In recent years,it has been found that cell transplantation has the potential for the treatment of white matter damage.OPCs are frequently used cells in cell transplantation therapy.With abilities of migration and myelinization,OPCs are the best seed cells for the treatment of white matter damage.Several studies have found that OPCs may not only replace impaired cells to reconstruct the structure and function of white matter,but also inhibit neuronal apoptosis,promote the proliferation of endogenous neural stem cells,and enhance the repairment of the blood-brain barrier.However,the clinical application of OPC transplantation therapy faces many challenges,such as the effectiveness,risk of tumorigenesis and immune rejection.With reference to these studies,this article reviewed the development of myelination,the obtainment of OPCs,the therapeutic mechanism as well as application research,and analyzed the current challenges of OPC transplantation,in order to provide a new direction for clinical treatment of white matter damage in preterm infants.关键词
少突胶质前体细胞/细胞移植/脑白质损伤/早产儿Key words
Oligodendrocyte precursor cell/Cell transplantation/White matter damage/Preterm infant引用本文复制引用
岳艳,张莉..少突胶质前体细胞移植对早产儿脑白质损伤的保护作用[J].中国当代儿科杂志,2018,20(4):326-331,6.基金项目
国家自然科学基金(81330016 （）
81630038 （）
81771634) （）
国家科技部重大专项(2017YFA0104200). （2017YFA0104200）
