中国防痨杂志2018，Vol.40Issue(2)：168-172,5.DOI:10.3969/j.issn.1000-6621.2018.02.011
环丝氨酸在耐多药结核病化学治疗中应用价值的探讨
Investigation on application of cycloserine in chemotherapy for multidrug-resistant tuberculosis
摘要
Abstract
Objective To evaluate the application of cycloserine in the treatment of multidrug-resistant tuberculosis (MDR-TB) and to provide a basis for further optimization of the chemotherapy for MDR-TB patients in China.Methods The clinical data,including treatment outcomes,of 143 MDR-TB patients in Hangzhou Red Cross Hospital and Wenzhou Central Hospital from 2014 to 2016 were collected.All patients received cycloserine-containing standard treatment according to the World Health Organization Treatment Guidelines for Drug-resistant Tuberculosis,2016 Update.The data such as treatment outcome,sputum negative conversion rate,and adverse events associated with drug were summarized.Results Among the 143 patients treated with cycloserine-containing regimen,the overall treatment success rate achieved 69.2％ (99/143).81.1％ (116/143) of patients had sputum culture conversion in the intensive phase.A total of 13 cases (9.1％,13/143) reported adverse events that were considered to be related with cycloserine,including 7 cases who complained of dizziness or headache,3 cases of limb numbness,2 cases of limb twitch and 1 case of depression.All adverse events were relieved by dose reduction or symptomatic treatment.Conclusion Cycloserine-containing standard therapy has high overall success rate and well tolerance for MDR-TB patients,which is worth to be applied in clinical.关键词
环丝氨酸/结核,肺/结核,抗多种药物性/治疗结果Key words
Cycloserine/Tuberculosis, pulmonary/Tuberculosis, multidrug-resistant/Treatment outcome引用本文复制引用
李杨,王飞,吴琍敏,朱敏,何贵清,孙峰,王晓萌,张文宏..环丝氨酸在耐多药结核病化学治疗中应用价值的探讨[J].中国防痨杂志,2018,40(2):168-172,5.基金项目
国家卫生计生委科学研究基金-浙江省医药卫生重大科技计划(WKJ-ZJ-07) （WKJ-ZJ-07）
浙江省重大科技专项计划项目(2014C03034) （2014C03034）
