中国防痨杂志2018，Vol.40Issue(2)：183-188,6.DOI:10.3969/j.issn.1000-6621.2018.02.014
881例疑似耐多药肺结核患者的耐药性分析
Analysis of drug susceptibility testing results of 881 patients with suspected multidrug-resistant pulmonary tuberculosis
杨新宇 1丁北川 1易俊莉 1邢青 1田丽丽 1代小伟 1张洁 1王嫩寒 1赵琰枫 1王甦民1
作者信息
- 1. 100035 北京结核病控制研究所中心实验室
- 折叠
摘要
Abstract
Objective To analyze the drug resistance situation of patients with suspected multidrug-resistant pulmonary tuberculosis (MDR-PTB) in TB control institutes and TB designated hospitals in Beijing,to provide suggestions for clinical diagnosis,treatment,and control.Methods We made a retrospective analysis,including preliminary bacteria identification and drug susceptibility testing of the bacteria isolated from the positive sputum specimens of the 881 suspected MDR-PTB patients from 14 TB control institutes and 6 TB designated hospitals in Beijing between January 2014 and December 2016.We collected their drug susceptibility testing results against INH,RFP,Sm,EMB,Lfx,Am,Cm,Pto,and PAS.SPSS 17.0 was used for statistical analysis.We analyzed and summarized the drug resistance situation of suspected MDR-PTB patients in those 3 years.Results In the 881 suspected MDR-PTB patients,the isolation rate of Mycobacterium tuberculosis complex group was 88.6％ (781/881).The isolation rate of non-tuberculous mycobacterium (NTM) was 11.4 ％ (100/881).The total drug resistant rate of the clinical isolates of Mycobacterium tuberculosis complex group was 33.3 ％ (260/781).The multidrug-resistance (MDR) rate was 17.2％ (134/781).The proportion of high-level of resistance rates (defined as ＞67.0％) against the four first-line TB drugs (INH,RFP,Sm and EMB) was 69.0％ (127/184),57.1％ (92/161),60.5％ (107/177) and 31.7％(19/60) respectively.Conclusion It is very necessary to carry out a drug sensitive test for the suspected MDR PTB patients in Beijing,and the epidemic situation of TB resistance faced in Beijing is still very severe.关键词
结核,肺/抗药性,细菌/微生物敏感性试验/北京市Key words
Tuberculosis,pulmonary/Drug resistance, bacterium/Microbial sensitivity tests/Beijing引用本文复制引用
杨新宇,丁北川,易俊莉,邢青,田丽丽,代小伟,张洁,王嫩寒,赵琰枫,王甦民..881例疑似耐多药肺结核患者的耐药性分析[J].中国防痨杂志,2018,40(2):183-188,6.
