中国临床心理学杂志2018，Vol.26Issue(2)：327-332,6.DOI:10.16128/j.cnki.1005-3611.2018.02.025
催产素对孤独症谱系障碍患者的影响:随机对照试验的系统综述和meta分析
The Impact of Oxytocin in ASD Patients:A Systematic Review and Meta-Analysis
摘要
Abstract
Objective:To review randomize controlled trials(RCTs) examining the effects of oxytocin(OT) administration on social function and restricted,repetitive behaviors in individuals with ASD.Methods:Literature searches were conducted in PubMed,Embase,Cochrane library,PsycINFO and Web of science,and reference lists from identified articles to retrieve relevant studies.The results were analyzed using stata14.0 software.Results:17 RCTs were included in this review.9 out of the 16 studies that examined social function reported improvements.Additionally,one out of the eight studies on restricted,repetitive behaviors,reported improvements following OT administration.Meta-analysis showed that the combined effect of OT on social function and restricted,repetitive behaviors was 0.167(P=-0.355) and 0.020(P=-0.901),respectively.Conclusion:Previous evidence revealed mixed findings about the effects of OT on ASD.Results from our meta-analyses suggest that OT has no significant effect on social function and restricted,repetitive behaviors.Given the limited number of RCTs,our summary of findings on the effectiveness of OT on ASD should still be considered tentative and further studies is still to be need.关键词
孤独症谱系障碍/催产素/社交功能/刻板行为/系统综述/meta分析Key words
Autism spectrum disorders/Oxytocin/Social function/Restricted, Repetitive behaviors/Systematic review/Meta-analysis分类
医药卫生引用本文复制引用
闫喜春,程怡,杨长江..催产素对孤独症谱系障碍患者的影响:随机对照试验的系统综述和meta分析[J].中国临床心理学杂志,2018,26(2):327-332,6.基金项目
国家自然科学基金项目(81501180)资助 （81501180）
华东师范大学研究生“科研创新实践”项目(ykc17047)资助 （ykc17047）
