中国临床药理学杂志2018，Vol.34Issue(3)：200-202,3.DOI:10.13699/j.cnki.1001-6821.2018.03.002
吡拉西坦注射液联合胞磷胆碱注射液治疗缺血性脑卒中的临床研究
Clinical trial of priacetam injection combined with citicoline injection in the treatment of ischemic stroke
摘要
Abstract
Objective To observe the clinical efficacy and safety of priacetam injection combined with citicoline injection in the treatment of ischemic stroke.Methods Ninety-four patients with ischemic stroke were randomly divided into control group and treatment group with 47 cases per group.Control group was given piracetam 20 g per time,qd,intravenous injection.Treatment group was given citicoline 0.5 g per time,qd,intravenous injection,on the basis of the control group.Two groups were treated for 14 days.The clinical efficacy,serum monocyte chemoattractant protein-1 (MCP-1),homocysteine (HCY),high density lipoprotein cholesterol (HDL-C),and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 87.23％ (41 cases/47 cases) and 63.83％ (30 cases/47 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:serum MCP-1 were (90.74 ± 10.33) and (120.71 ± 15.42) pg · mL-1,HCY were (16.68 ±2.24) and (21.01 ±3.03) μmol · L-1,HDL-C were (1.31 ±0.16) and (1.12 ±0.13) mmol · L-1,the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions in treatment group were insomnia,lack of appetite and dry mouth,which in control group were rash,diarrhea and hypotension.The incidences of adverse drug reactions in treatment and control groups were 10.64％ and 14.89％ without significant difference (P ＞ 0.05).Conclusion Priacetam injection combined with eitieoline injection has a definitive clinical efficacy in the treatment of ischemic stroke,which can significantly reduce the levels of serum MCP-1 and HCY,improve the levels of HDL-C,without increasing the incidence of adverse drug reactions.关键词
吡拉西坦注射液/胞磷胆碱注射液/缺血性脑卒中/安全性Key words
priacetam injection/citicoline injection/ischemic stroke/safety分类
医药卫生引用本文复制引用
孟祥博,陈丽娜..吡拉西坦注射液联合胞磷胆碱注射液治疗缺血性脑卒中的临床研究[J].中国临床药理学杂志,2018,34(3):200-202,3.基金项目
浙江省医药卫生科技计划基金资助项目(2012KYB243) （2012KYB243）
浙江省中医药科学研究基金资助项目(2015ZA132) （2015ZA132）
