中国临床药理学杂志2018，Vol.34Issue(3)：212-214,3.DOI:10.13699/j.cnki.1001-6821.2018.03.006
贝那普利片联合美托洛尔片治疗老年高血压合并心力衰竭的临床研究
Clinical trial of benazepril tablets combined with metoprolol tablets in the treatment of elderly hypertension complicated with heart failure
摘要
Abstract
Objective To observe the clinical efficacy and safety of benazepril tablets combined with metoprolol tablets in the treatment of elderly hypertension complicated with heart failure.Methods One hundred elderly hypertension complicated with heart failure were randomly divided into A group (n =33 cases),B group (n =33 cases) and C group (n =34 cases).A group received benazepril 10 mg each time,qd,orally.B group received metoprolol 100 mg each time,bid,orally.C group received benazepril 10 mg each time,qd,orally + metoprolol 100 mg each time,bid,orally.Three groups were treated for 6 months.The clinical efficacy,blood pressure,cardiac ftmction indexes,and adverse drug reactions were compared between the three groups.Results After treatment,the total effective rates of A,B and C groups were 75.76％ (25 cases/33 cases),72.73％ (24 cases/33 cases) and 91.18％ (31 cases/34 cases),respectively.The differences between C group and A,B groups were statistically significant (all P ＜ 0.05).After treatment,the main indexes in A,B,C groups were compared:systolic blood pressure were (141.61 ± 17.22),(142.23 ± 15.34) and (121.73 ± 13.23) mmHg,diastolic blood pressure were (88.04 ± 9.38),(86.96 ± 9.54) and (79.81 ± 9.19) mmHg,left ventricular ejection fraction were (41.03±4.31)％,(41.10 ± 4.32)％ and (51.54 ± 5.38)％,left ventricular end systolic diameter were (53.41 ±5.04),(52.83 ±5.13) and (43.41 ±4.17)mm,left ventricular end diastolic diameter were (45.93 ±4.86),(45.80 ±4.93) and (38.92 ±3.81)mm,distance of 6 min walking test were (328.95 ±68.50),(319.61 ±67.83) and (360.80 ± 69.89) m.The differences between C group and A,B groups were statistically significant (all P ＜ 0.05).The adverse drug reactions in three groups were gastrointestinal reactions and dry cough.The incidences of adverse drug reactions in A,B,C groups were 12.12％,15.15％ and 14.70％ without significant differences (all P ＞ 0.05).Conclusion Benazepril tablets combined with metoprotol tablets have a definitive clinical efficacy in the treatment of elderly hypertension complicated with heart failure,which can significantly reduce the patient's blood pressure and improve the patient's heart function,without increasing the incidence of adverse drug reactions.关键词
贝那普利片/美托洛尔片/高血压/心力衰竭/安全性Key words
benazepril tablet/metoprolol tablet/hypertension/heart failure/safety分类
医药卫生引用本文复制引用
刘继民,尚树忠,郑轶,郭三强,刘恒亮..贝那普利片联合美托洛尔片治疗老年高血压合并心力衰竭的临床研究[J].中国临床药理学杂志,2018,34(3):212-214,3.基金项目
河南省医学科技攻关计划基金资助项目(201303230) （201303230）
