中国临床药理学杂志2018，Vol.34Issue(3)：215-217,3.DOI:10.13699/j.cnki.1001-6821.2018.03.007
阿托伐他汀钙片联合骨髓间充质干细胞移植治疗心肌梗死的临床研究
Clinical trial of atorvastatin calcium tablets combined with bone marrow mesenchymal stem cell transplantation in the treatment of myocardial infarction
摘要
Abstract
Objective To observe the clinical efficacy and safety of atorvastatin calcium tablets combined with bone marrow mesenchymal stem cell transplantation in the treatment of myocardial infarction.Methods Eighty patients with myocardial infarction were randomly divided into control and treatment groups with 40 cases per group.Control group was treated with atorvastatin calcium 20 mg per time,qd,orally,treat for 1 month.Treatment group was treated with bone marrow mesenchymal stem cell transplantation on the basis of the control group.The clinical efficacy,the levels of inflammatory factors,cardiac function and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 92.50％ (37 cases/40 cases) and 82.50％ (33 cases/40 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:tumor necrosis factor alpha were (1.36 ± 0.85) and (2.54 ± 0.77) μg · L-1,interleukin-6 were (5.28 ± 0.76) and (9.86 ± 1.22) ng · L-1,interleukin-8 were (16.38 ± 4.69) and (21.54 ± 5.47) ng · L-1,high sensitivity C-reactive protein were (3.64 ± 1.08) and (5.74 ± 1.29)mg · L-1,left ventricular end-diastolic dimension were (40.26 ± 5.29) and (45.34 ±5.20) mm,left ventricular end-systolic dimension were (53.36 ± 5.41) and (60.42 ± 5.37) mm,the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions in the two groups were mild transaminase increasing.The incidences of adverse drug reactions in treatment and control groups were 7.50％ and 5.00％ without significant difference (P ＞ 0.05).Conclusion Atorvastatin calcium tablets combined with bone marrow mesenchymal stem cell transplantation have a definitive clinical efficacy in the treatment of myocardial infarction,which can statistically reduce the levels of inflammatory cytokines and improve the heart function,without increasing the incidence of adverse drug reactions.关键词
阿托伐他汀钙片/骨髓间充质干细胞移植/心肌梗死/炎症因子/心功能Key words
atorvastatin calcium tablet/bone marrow mesenchymal stem cell transplantation/myocardial infarction/inflammatory factor/heart function分类
医药卫生引用本文复制引用
史磊,孔庆瑞,郑红艳,陈会强..阿托伐他汀钙片联合骨髓间充质干细胞移植治疗心肌梗死的临床研究[J].中国临床药理学杂志,2018,34(3):215-217,3.基金项目
山东省自然科学基金资助项目(2014ZRE27592) （2014ZRE27592）
